TY - JOUR
T1 - Depot-medroxyprogesterone acetate use is associated with decreased risk of ovarian cancer
T2 - The mounting evidence of a protective role of progestins
AU - Phung, Minh Tung
AU - Lee, Alice W.
AU - Wu, Anna H.
AU - Berchuck, Andrew
AU - Cho, Kathleen R.
AU - Cramer, Daniel W.
AU - Doherty, Jennifer Anne
AU - Goodman, Marc T.
AU - Hanley, Gillian E.
AU - Harris, Holly R.
AU - McLean, Karen
AU - Modugno, Francesmary
AU - Moysich, Kirsten B.
AU - Mukherjee, Bhramar
AU - Schildkraut, Joellen M.
AU - Terry, Kathryn L.
AU - Titus, Linda J.
AU - Jordan, Susan J.
AU - Webb, Penelope M.
AU - Pike, Malcolm C.
AU - Pearce, Celeste Leigh
N1 - Publisher Copyright:
2021 American Association for Cancer Research.
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Background: Combined oral contraceptive use is associated with a decreased risk of invasive epithelial ovarian cancer (ovarian cancer). There is suggestive evidence of an inverse association between progestin-only contraceptive use and ovarian cancer risk, but previous studies have been underpowered. Methods: The current study used primary data from 7,977 women with ovarian cancer and 11,820 control women in seven case–control studies from the Ovarian Cancer Association Consortium to evaluate the association between use of depot-medroxyprogesterone acetate (DMPA), an injectable progestin-only contraceptive, and ovarian cancer risk. Logistic models were fit to determine the association between ever use of DMPA and ovarian cancer risk overall and by histotype. A systematic review of the association between DMPA use and ovarian cancer risk was conducted. Results: Ever use of DMPA was associated with a 35% decreased risk of ovarian cancer overall (OR, 0.65; 95% confidence interval, 0.50–0.85). There was a statistically significant trend of decreasing risk with increasing duration of use (Ptrend < 0.001). The systematic review yielded six studies, four of which showed an inverse association and two showed increased risk. Conclusions: DMPA use appears to be associated with a decreased risk of ovarian cancer in a duration-dependent manner based on the preponderance of evidence. Further study of the mechanism through which DMPA use is associated with ovarian cancer is warranted. Impact: The results of this study are of particular interest given the rise in popularity of progestin-releasing intrauterine devices that have a substantially lower progestin dose than that in DMPA, but may have a stronger local effect.
AB - Background: Combined oral contraceptive use is associated with a decreased risk of invasive epithelial ovarian cancer (ovarian cancer). There is suggestive evidence of an inverse association between progestin-only contraceptive use and ovarian cancer risk, but previous studies have been underpowered. Methods: The current study used primary data from 7,977 women with ovarian cancer and 11,820 control women in seven case–control studies from the Ovarian Cancer Association Consortium to evaluate the association between use of depot-medroxyprogesterone acetate (DMPA), an injectable progestin-only contraceptive, and ovarian cancer risk. Logistic models were fit to determine the association between ever use of DMPA and ovarian cancer risk overall and by histotype. A systematic review of the association between DMPA use and ovarian cancer risk was conducted. Results: Ever use of DMPA was associated with a 35% decreased risk of ovarian cancer overall (OR, 0.65; 95% confidence interval, 0.50–0.85). There was a statistically significant trend of decreasing risk with increasing duration of use (Ptrend < 0.001). The systematic review yielded six studies, four of which showed an inverse association and two showed increased risk. Conclusions: DMPA use appears to be associated with a decreased risk of ovarian cancer in a duration-dependent manner based on the preponderance of evidence. Further study of the mechanism through which DMPA use is associated with ovarian cancer is warranted. Impact: The results of this study are of particular interest given the rise in popularity of progestin-releasing intrauterine devices that have a substantially lower progestin dose than that in DMPA, but may have a stronger local effect.
UR - https://www.scopus.com/pages/publications/85105483857
U2 - 10.1158/1055-9965.EPI-20-1355
DO - 10.1158/1055-9965.EPI-20-1355
M3 - Article
C2 - 33619020
AN - SCOPUS:85105483857
SN - 1055-9965
VL - 30
SP - 927
EP - 935
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 5
ER -