Abstract
The dehydration kinetics of theophylline monohydrate and ampicillin trihydrate were measured by an X‐ray powder diffraction technique in an open system. In the case of theophylline, the hydrate transforms directly to a crystalline anhydrous form with apparent zero‐order kinetics. The loss of water from ampicillin trihydrate results in an amorphous state. Commercial micronized ampicillin trihydrate, which contains a small amount of excipients, exhibits a different kinetic order and a faster rate of transformation.
| Original language | English |
|---|---|
| Pages (from-to) | 791-794 |
| Number of pages | 4 |
| Journal | Journal of Pharmaceutical Sciences |
| Volume | 62 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1973 |
Keywords
- Ampicillin trihydrate—dehydration kinetics measured using X‐ray powder diffraction technique
- Phase stability, theophylline monohydrate and ampicillin trihydrate—dehydration kinetics studied using X‐ray powder diffraction technique
- Solid‐state phase transformations—dehydration of theophylline monohydrate and ampicillin trihydrate studied using X‐ray powder diffraction technique
- Theophylline monohydrate—dehydration kinetics measured using X‐ray powder diffraction technique
- X‐ray powder diffraction technique—used to measure dehydration kinetics for theophylline monohydrate and ampicillin trihydrate
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