Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Grigory S. Filonov; Arie Krumholz; Jun Xia; Junjie Yao; Lihong V. Wang; Vladislav V. Verkhusha

doi:10.1002/anie.201107026

Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Grigory S. Filonov
, Arie Krumholz
, Jun Xia
, Junjie Yao
, Lihong V. Wang
, Vladislav V. Verkhusha

Department of Biomedical Engineering

Albert Einstein College of Medicine
Washington University St. Louis

Research output: Contribution to journal › Article › peer-review

160 Scopus citations

Abstract

Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.

Original language	English
Pages (from-to)	1448-1451
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	6
DOIs	https://doi.org/10.1002/anie.201107026
State	Published - Feb 6 2012

Keywords

absorption
cancer
fluorescent proteins
imaging agents
photoacoustic imaging

Access to Document

10.1002/anie.201107026

Cite this

@article{54963115abde4661bb5487b049abf658,

title = "Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe",

abstract = "Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.",

keywords = "absorption, cancer, fluorescent proteins, imaging agents, photoacoustic imaging",

author = "Filonov, \{Grigory S.\} and Arie Krumholz and Jun Xia and Junjie Yao and Wang, \{Lihong V.\} and Verkhusha, \{Vladislav V.\}",

year = "2012",

month = feb,

day = "6",

doi = "10.1002/anie.201107026",

language = "English",

volume = "51",

pages = "1448--1451",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "6",

}

TY - JOUR

T1 - Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

AU - Filonov, Grigory S.

AU - Krumholz, Arie

AU - Xia, Jun

AU - Yao, Junjie

AU - Wang, Lihong V.

AU - Verkhusha, Vladislav V.

PY - 2012/2/6

Y1 - 2012/2/6

N2 - Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.

AB - Skin-deep: The combination of a near-infrared fluorescent protein (iRFP) and deep-tissue photoacoustic tomography clearly demonstrates the superiority of iRFP over other genetically encoded probes. Impressive resolution (280 μm lateral and 75 μm axial) was obtained at a depth of 4mm in a live animal, and volumetric images of a tumor were produced (see image), thus allowing the spatially resolved monitoring of its development.

KW - absorption

KW - cancer

KW - fluorescent proteins

KW - imaging agents

KW - photoacoustic imaging

UR - https://www.scopus.com/pages/publications/84863018064

U2 - 10.1002/anie.201107026

DO - 10.1002/anie.201107026

M3 - Article

C2 - 22213541

AN - SCOPUS:84863018064

SN - 1433-7851

VL - 51

SP - 1448

EP - 1451

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 6

ER -

Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this