@inbook{d4bbf877026c4c98a47e411c729227be,
title = "Cytoskeletal Contribution to Cell Stiffness Due to Osmotic Swelling; Extending the Donnan Equilibrium",
abstract = "Cell volume regulation is commonly analyzed with a model of a closed semipermeable membrane filled with impermeant mobile solutes and the Donnan Equilibrium is used to predict the hydrostatic pressure. This traditional model ignores the fact that most cells are filled with a crosslinked cytoskeleton that is elastic and can be stretched or compressed like a sponge with no obvious need to move mobile solutes. However, calculations show that under osmotic stress, the elastic energy of the cytoskeleton is far greater than the elastic energy of the membrane. Here we expand the traditional Donnan model to include the elasticity of a cytoskeleton with fixed charges and show that cell stiffening happens without a membrane.",
keywords = "Cytoskeleton, Elasticity, Osmosis, Poroelasticity, Volume",
author = "Chao, \{Pei Chuan\} and Mettupalayam Sivaselvan and Frederick Sachs",
note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/bs.ctm.2018.07.002",
language = "English",
isbn = "9780128154564",
series = "Current Topics in Membranes",
publisher = "Academic Press Inc.",
pages = "83--96",
editor = "Irena Levitane and Eric Delpire and Hector Rasgado-Flores",
booktitle = "Current Topics in Membranes",
address = "United States",
}