Current taxane formulations and emerging cabazitaxel delivery systems

Boyang Sun; Robert M. Straubinger; Jonathan F. Lovell

doi:10.1007/s12274-018-2171-0

Current taxane formulations and emerging cabazitaxel delivery systems

SUNY Buffalo

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes (i.e. paclitaxel and docetaxel) have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

Original language	English
Pages (from-to)	5193-5218
Number of pages	26
Journal	Nano Research
Volume	11
Issue number	10
DOIs	https://doi.org/10.1007/s12274-018-2171-0
State	Published - Oct 1 2018

Keywords

cabazitaxel
drug delivery systems
Jevtana
nanocarriers
taxanes

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10.1007/s12274-018-2171-0

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title = "Current taxane formulations and emerging cabazitaxel delivery systems",

abstract = "Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes (i.e. paclitaxel and docetaxel) have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.",

keywords = "cabazitaxel, drug delivery systems, Jevtana, nanocarriers, taxanes",

author = "Boyang Sun and Straubinger, \{Robert M.\} and Lovell, \{Jonathan F.\}",

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AU - Sun, Boyang

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AU - Lovell, Jonathan F.

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N2 - Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes (i.e. paclitaxel and docetaxel) have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

AB - Cabazitaxel is a second-generation taxane with promising anti-tumor activity and is approved for treating hormone-refractory metastatic prostate cancer previously treated with docetaxel. Although first-generation taxanes (i.e. paclitaxel and docetaxel) have sparked broad interest in a variety of drug delivery vehicles, fewer have yet been developed for cabazitaxel. This review summarizes several clinical-stage approaches for taxane formulation and recent efforts to develop novel cabazitaxel delivery systems.

KW - cabazitaxel

KW - drug delivery systems

KW - Jevtana

KW - nanocarriers

KW - taxanes

UR - https://www.scopus.com/pages/publications/85053230576

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DO - 10.1007/s12274-018-2171-0

M3 - Review article

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VL - 11

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JO - Nano Research

JF - Nano Research

IS - 10

ER -

Current taxane formulations and emerging cabazitaxel delivery systems

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Keywords

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