Current insights into neural crest cell development and pathologies

Rebekah M. Charney; Maneeshi S. Prasad; Martín I. García-Castro

doi:10.1016/B978-0-12-817988-8.00011-7

Current insights into neural crest cell development and pathologies

Rebekah M. Charney
, Maneeshi S. Prasad
, Martín I. García-Castro

Biochemistry

University of California at Riverside

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Neural crest is a multipotent embryonic population unique to vertebrates which arises early in development and migrates extensively throughout the body. Exhibiting remarkable differentiation capacity, neural crest cells give rise to neurons and glia of the peripheral nervous system, in addition to pigment cells and craniofacial bone and cartilage. Improper neural crest formation and differentiation results in numerous human pathologies. In this chapter, we discuss the early formation of neural crest cells, highlight neurocristopathies revealing defects in the peripheral nervous system, and remark on pluripotent stem cell models used to address human disease.

Original language	English
Title of host publication	Diagnosis, Management and Modeling of Neurodevelopmental Disorders
Subtitle of host publication	The Neuroscience of Development
Publisher	Elsevier
Pages	127-137
Number of pages	11
ISBN (Electronic)	9780128179888
ISBN (Print)	9780128179895
DOIs	https://doi.org/10.1016/B978-0-12-817988-8.00011-7
State	Published - Jan 1 2021

Keywords

BMP
FGF
Gene regulatory network
Induction
Neural crest
Neural plate border
Neurocristopathy
Peripheral nervous system
Specification
WNT

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10.1016/B978-0-12-817988-8.00011-7

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AU - Charney, Rebekah M.

AU - Prasad, Maneeshi S.

AU - García-Castro, Martín I.

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Y1 - 2021/1/1

N2 - Neural crest is a multipotent embryonic population unique to vertebrates which arises early in development and migrates extensively throughout the body. Exhibiting remarkable differentiation capacity, neural crest cells give rise to neurons and glia of the peripheral nervous system, in addition to pigment cells and craniofacial bone and cartilage. Improper neural crest formation and differentiation results in numerous human pathologies. In this chapter, we discuss the early formation of neural crest cells, highlight neurocristopathies revealing defects in the peripheral nervous system, and remark on pluripotent stem cell models used to address human disease.

AB - Neural crest is a multipotent embryonic population unique to vertebrates which arises early in development and migrates extensively throughout the body. Exhibiting remarkable differentiation capacity, neural crest cells give rise to neurons and glia of the peripheral nervous system, in addition to pigment cells and craniofacial bone and cartilage. Improper neural crest formation and differentiation results in numerous human pathologies. In this chapter, we discuss the early formation of neural crest cells, highlight neurocristopathies revealing defects in the peripheral nervous system, and remark on pluripotent stem cell models used to address human disease.

KW - BMP

KW - FGF

KW - Gene regulatory network

KW - Induction

KW - Neural crest

KW - Neural plate border

KW - Neurocristopathy

KW - Peripheral nervous system

KW - Specification

KW - WNT

UR - https://www.scopus.com/pages/publications/85129353759

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DO - 10.1016/B978-0-12-817988-8.00011-7

M3 - Chapter

AN - SCOPUS:85129353759

SN - 9780128179895

SP - 127

EP - 137

BT - Diagnosis, Management and Modeling of Neurodevelopmental Disorders

PB - Elsevier

ER -

Current insights into neural crest cell development and pathologies

Abstract

Keywords

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