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Correction: Gene Expression Profiling Identifies Important Genes Affected by R2 Compound Disrupting FAK and P53 Complex (Cancers, (2014), 6, 1, (166-178), 10.3390/cancers6010166)

  • Vita M. Golubovskaya
  • , Baotran Ho
  • , Jeffrey Conroy
  • , Song Liu
  • , Dan Wang
  • , William G. Cance
  • Roswell Park Cancer Institute

Research output: Contribution to journalComment/debate

Abstract

In the original publication [1], there was a mistake in Figure 3A as published. The two colony images in the lower panel were similar. The corrected Figure 3A appears below. The corresponding Figure 3 legend has been updated to reflect the removal of some of the clonogenic assays. Figure 3. R2 sensitized HCT116 cells to M13 and Nutlin. A clonogenicity assay was performed on HCT116p53+/+ cells or HCT116p53/ treated for one week either with R2 alone, M13 alone, or with a combination of R2 and M13 (A), and R2 alone, Nutlin-1 alone, or with a combination of R2 and Nutlin-1 (B). The representative clonogenicity assay of several independent experiments is shown. A clonogenicity assay image of HCT116p53/ in (A) is not shown. Colonies were counted and quantification is shown with the panels on the right. Bars show the average number of colonies per treatment from two to four independent experiments. * Student’s t-test, p < 0.05, R2 + M13 or R2 + Nutlin-1 versus untreated HCT116p53+/+ and HCT116 p53−/− or treated cells with a single agent. The p-values are shown in a combination group versus a single agent. The text in Section 2.2 The R2 Sensitized Cancer Cells to M13 (Disrupting FAK and Mdm-2) and Nutlin-1 (Disrupting p53 and Mdm-2) Treatments, paragraph 2 has been updated to ‘Since Nutlin-1 that disrupts p53 and Mdm-2 protein interaction [15], also can induce p53, we treated HCT116 p53+/+ and HCT53−/− cells with either R2 alone, Nutlin-1 alone or with combination of R2 and Nutlin-1 (Figure 3B)’. The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.

Original languageEnglish
Article number526
JournalCancers
Volume18
Issue number3
DOIs
StatePublished - Feb 2026

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