Control systems technology in the advanced manufacturing of biologic drugs

Amos E. Lu; Joel A. Paulson; Nicholas J. Mozdzierz; Alan Stockdale; Ashlee N.Ford Versypt; Kerry R. Love; J. Christopher Love; Richard D. Braatz

doi:10.1109/CCA.2015.7320824

Control systems technology in the advanced manufacturing of biologic drugs

Amos E. Lu
, Joel A. Paulson
, Nicholas J. Mozdzierz
, Alan Stockdale
, Ashlee N.Ford Versypt
, Kerry R. Love
, J. Christopher Love
, Richard D. Braatz

Department of Chemical and Biological Engineering

Massachusetts Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

16 Scopus citations

Abstract

The paper focuses on systems engineering challenges for biomanufacturing, as exemplified by the Integrated and Scalable Cyto-Technology (InSCyT) bio-manufacturing platform under the Defense Advanced Research Projects Agency (DARPA) Biologically-derived Medicines on Demand (Bio-MOD) program. One goal of the project is to apply modeling and simulation techniques to the design, control, and optimization of biomanufacturing operations. In this paper, we present models and control strategies for the unit operations within the InSCyT platform, including a perfusion bioreactor, several packed bed and membrane chromatography steps, and a conductivity- and pH-controlled buffer mixing unit.

Original language	English
Title of host publication	2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1505-1515
Number of pages	11
ISBN (Electronic)	9781479977871
DOIs	https://doi.org/10.1109/CCA.2015.7320824
State	Published - Nov 4 2015
Event	IEEE Conference on Control and Applications, CCA 2015 - Sydney, Australia Duration: Sep 21 2015 → Sep 23 2015

Publication series

Name	2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings

Conference

Conference	IEEE Conference on Control and Applications, CCA 2015
Country/Territory	Australia
City	Sydney
Period	09/21/15 → 09/23/15

Access to Document

10.1109/CCA.2015.7320824

Cite this

Lu, A. E., Paulson, J. A., Mozdzierz, N. J., Stockdale, A., Versypt, A. N. F., Love, K. R., Love, J. C., & Braatz, R. D. (2015). Control systems technology in the advanced manufacturing of biologic drugs. In 2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings (pp. 1505-1515). Article 7320824 (2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/CCA.2015.7320824

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title = "Control systems technology in the advanced manufacturing of biologic drugs",

abstract = "The paper focuses on systems engineering challenges for biomanufacturing, as exemplified by the Integrated and Scalable Cyto-Technology (InSCyT) bio-manufacturing platform under the Defense Advanced Research Projects Agency (DARPA) Biologically-derived Medicines on Demand (Bio-MOD) program. One goal of the project is to apply modeling and simulation techniques to the design, control, and optimization of biomanufacturing operations. In this paper, we present models and control strategies for the unit operations within the InSCyT platform, including a perfusion bioreactor, several packed bed and membrane chromatography steps, and a conductivity- and pH-controlled buffer mixing unit.",

author = "Lu, \{Amos E.\} and Paulson, \{Joel A.\} and Mozdzierz, \{Nicholas J.\} and Alan Stockdale and Versypt, \{Ashlee N.Ford\} and Love, \{Kerry R.\} and Love, \{J. Christopher\} and Braatz, \{Richard D.\}",

note = "Publisher Copyright: {\textcopyright} 2015 IEEE.; IEEE Conference on Control and Applications, CCA 2015 ; Conference date: 21-09-2015 Through 23-09-2015",

year = "2015",

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doi = "10.1109/CCA.2015.7320824",

language = "English",

series = "2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

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}

Lu, AE, Paulson, JA, Mozdzierz, NJ, Stockdale, A, Versypt, ANF, Love, KR, Love, JC & Braatz, RD 2015, Control systems technology in the advanced manufacturing of biologic drugs. in 2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings., 7320824, 2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings, Institute of Electrical and Electronics Engineers Inc., pp. 1505-1515, IEEE Conference on Control and Applications, CCA 2015, Sydney, Australia, 09/21/15. https://doi.org/10.1109/CCA.2015.7320824

Control systems technology in the advanced manufacturing of biologic drugs. / Lu, Amos E.; Paulson, Joel A.; Mozdzierz, Nicholas J. et al.
2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings. Institute of Electrical and Electronics Engineers Inc., 2015. p. 1505-1515 7320824 (2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Lu, Amos E.

AU - Paulson, Joel A.

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AU - Versypt, Ashlee N.Ford

AU - Love, Kerry R.

AU - Love, J. Christopher

AU - Braatz, Richard D.

PY - 2015/11/4

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N2 - The paper focuses on systems engineering challenges for biomanufacturing, as exemplified by the Integrated and Scalable Cyto-Technology (InSCyT) bio-manufacturing platform under the Defense Advanced Research Projects Agency (DARPA) Biologically-derived Medicines on Demand (Bio-MOD) program. One goal of the project is to apply modeling and simulation techniques to the design, control, and optimization of biomanufacturing operations. In this paper, we present models and control strategies for the unit operations within the InSCyT platform, including a perfusion bioreactor, several packed bed and membrane chromatography steps, and a conductivity- and pH-controlled buffer mixing unit.

AB - The paper focuses on systems engineering challenges for biomanufacturing, as exemplified by the Integrated and Scalable Cyto-Technology (InSCyT) bio-manufacturing platform under the Defense Advanced Research Projects Agency (DARPA) Biologically-derived Medicines on Demand (Bio-MOD) program. One goal of the project is to apply modeling and simulation techniques to the design, control, and optimization of biomanufacturing operations. In this paper, we present models and control strategies for the unit operations within the InSCyT platform, including a perfusion bioreactor, several packed bed and membrane chromatography steps, and a conductivity- and pH-controlled buffer mixing unit.

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M3 - Conference contribution

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BT - 2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

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Lu AE, Paulson JA, Mozdzierz NJ, Stockdale A, Versypt ANF, Love KR et al. Control systems technology in the advanced manufacturing of biologic drugs. In 2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings. Institute of Electrical and Electronics Engineers Inc. 2015. p. 1505-1515. 7320824. (2015 IEEE Conference on Control and Applications, CCA 2015 - Proceedings). doi: 10.1109/CCA.2015.7320824

Control systems technology in the advanced manufacturing of biologic drugs

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