Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [d-Pen2,d-Pen5]enkephalin

Francois Jenck; Michael Bozarth; Roy A. Wise

doi:10.1016/0006-8993(88)91580-6

Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [d-Pen²,d-Pen⁵]enkephalin

Francois Jenck
, Michael Bozarth
, Roy A. Wise

Psychology

Concordia University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Unilateral ventral tegmental area (VTA) injections of morphine and [d-Pen²,d-Pen⁵]enkephalin (DPDPE), caused contraversive circling at doses of 1.2, 12, and 24 nmol. Similar doses of the selective κ-agonist U-50,488H were ineffective. These data suggest a common mechanism for the circling, locomotion and facilitation of brain stimulation reward caused by VTA morphine, and distinguish this mechanism for that of feeding which is caused by both morphine and κ-actions in this region.

Original language	English
Pages (from-to)	382-386
Number of pages	5
Journal	Brain Research
Volume	450
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(88)91580-6
State	Published - May 31 1988

Keywords

Morphine
Opioid
Rotation
Ventral tegmental area
κ-Agonist
μ-Agonist
σ-Agonist

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10.1016/0006-8993(88)91580-6

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abstract = "Unilateral ventral tegmental area (VTA) injections of morphine and [d-Pen2,d-Pen5]enkephalin (DPDPE), caused contraversive circling at doses of 1.2, 12, and 24 nmol. Similar doses of the selective κ-agonist U-50,488H were ineffective. These data suggest a common mechanism for the circling, locomotion and facilitation of brain stimulation reward caused by VTA morphine, and distinguish this mechanism for that of feeding which is caused by both morphine and κ-actions in this region.",

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AU - Jenck, Francois

AU - Bozarth, Michael

AU - Wise, Roy A.

PY - 1988/5/31

Y1 - 1988/5/31

N2 - Unilateral ventral tegmental area (VTA) injections of morphine and [d-Pen2,d-Pen5]enkephalin (DPDPE), caused contraversive circling at doses of 1.2, 12, and 24 nmol. Similar doses of the selective κ-agonist U-50,488H were ineffective. These data suggest a common mechanism for the circling, locomotion and facilitation of brain stimulation reward caused by VTA morphine, and distinguish this mechanism for that of feeding which is caused by both morphine and κ-actions in this region.

AB - Unilateral ventral tegmental area (VTA) injections of morphine and [d-Pen2,d-Pen5]enkephalin (DPDPE), caused contraversive circling at doses of 1.2, 12, and 24 nmol. Similar doses of the selective κ-agonist U-50,488H were ineffective. These data suggest a common mechanism for the circling, locomotion and facilitation of brain stimulation reward caused by VTA morphine, and distinguish this mechanism for that of feeding which is caused by both morphine and κ-actions in this region.

KW - Morphine

KW - Opioid

KW - Rotation

KW - Ventral tegmental area

KW - κ-Agonist

KW - μ-Agonist

KW - σ-Agonist

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ER -

Contraversive circling induced by ventral tegmental microinjections of moderate doses of morphine and [d-Pen²,d-Pen⁵]enkephalin

Abstract

Keywords

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