Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute

J. X. Wilson; N. H. West; M. Amies; E. Michalska

doi:10.1016/0304-3940(85)90570-1

Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute

J. X. Wilson
, N. H. West
, M. Amies
, E. Michalska

Department of Exercise and Nutrition Sciences

University of Saskatchewan

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The reappearance of circulating catecholamines (CAs) after transfusion with perfluorocarbon blood substitute and the importance of blood for CA conjugation were determined in rats. Arterial plasma concentrations of unconjugated (i.e. free), sulfoconjugated and glucuronoconjugated forms of the CAs dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cannulated, anesthetized, control rats remained stable during the 4.5 h long experiments. Contrarily, in parallel experiments with another group of rats, replacement of blood by the perfluorocarbon blood substitute initially lowered the arterial concentrations of DA glucuronide, free AD and AD glucuronide; subsequently, free DA, NA and AD increased, followed by delayed increases in conjugated CA levels. These changes in CA concentrations preceded a fall in systemic arterial blood pressure (p_a) and thus were not the consequences of hypotension.

Original language	English
Pages (from-to)	329-333
Number of pages	5
Journal	Neuroscience Letters
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(85)90570-1
State	Published - Dec 18 1985

Keywords

blood pressure
conjugated catecholamine
heart rate perfluorotributylamine
resuscitation fluid

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10.1016/0304-3940(85)90570-1

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title = "Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute",

abstract = "The reappearance of circulating catecholamines (CAs) after transfusion with perfluorocarbon blood substitute and the importance of blood for CA conjugation were determined in rats. Arterial plasma concentrations of unconjugated (i.e. free), sulfoconjugated and glucuronoconjugated forms of the CAs dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cannulated, anesthetized, control rats remained stable during the 4.5 h long experiments. Contrarily, in parallel experiments with another group of rats, replacement of blood by the perfluorocarbon blood substitute initially lowered the arterial concentrations of DA glucuronide, free AD and AD glucuronide; subsequently, free DA, NA and AD increased, followed by delayed increases in conjugated CA levels. These changes in CA concentrations preceded a fall in systemic arterial blood pressure (pa) and thus were not the consequences of hypotension.",

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T1 - Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute

AU - Wilson, J. X.

AU - West, N. H.

AU - Amies, M.

AU - Michalska, E.

PY - 1985/12/18

Y1 - 1985/12/18

N2 - The reappearance of circulating catecholamines (CAs) after transfusion with perfluorocarbon blood substitute and the importance of blood for CA conjugation were determined in rats. Arterial plasma concentrations of unconjugated (i.e. free), sulfoconjugated and glucuronoconjugated forms of the CAs dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cannulated, anesthetized, control rats remained stable during the 4.5 h long experiments. Contrarily, in parallel experiments with another group of rats, replacement of blood by the perfluorocarbon blood substitute initially lowered the arterial concentrations of DA glucuronide, free AD and AD glucuronide; subsequently, free DA, NA and AD increased, followed by delayed increases in conjugated CA levels. These changes in CA concentrations preceded a fall in systemic arterial blood pressure (pa) and thus were not the consequences of hypotension.

AB - The reappearance of circulating catecholamines (CAs) after transfusion with perfluorocarbon blood substitute and the importance of blood for CA conjugation were determined in rats. Arterial plasma concentrations of unconjugated (i.e. free), sulfoconjugated and glucuronoconjugated forms of the CAs dopamine (DA), noradrenaline (NA) and adrenaline (AD) in cannulated, anesthetized, control rats remained stable during the 4.5 h long experiments. Contrarily, in parallel experiments with another group of rats, replacement of blood by the perfluorocarbon blood substitute initially lowered the arterial concentrations of DA glucuronide, free AD and AD glucuronide; subsequently, free DA, NA and AD increased, followed by delayed increases in conjugated CA levels. These changes in CA concentrations preceded a fall in systemic arterial blood pressure (pa) and thus were not the consequences of hypotension.

KW - blood pressure

KW - conjugated catecholamine

KW - heart rate perfluorotributylamine

KW - resuscitation fluid

UR - https://www.scopus.com/pages/publications/0022339084

U2 - 10.1016/0304-3940(85)90570-1

DO - 10.1016/0304-3940(85)90570-1

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SN - 0304-3940

VL - 62

SP - 329

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Conjugated catecholamines in rats transfused with perfluorocarbon blood substitute

Abstract

Keywords

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