@inproceedings{df029ffd3b904b93821878c4ca18553d,
title = "Conjugate systems using delocalized cationic dyes as a carrier of photosensitizers to mitochondria",
abstract = "Following Photofrin, the first generation photosensitizer, several second generation photosensitizers have been developed with improved characteristics. More recently, third generation photosensitizers are proposed to achieve higher selectivity toward cancer cells/ tumor tissue. Elevated mitochondrial membrane potential of malignant cells has tested as a tool for preferential uptake of certain photosensitizers to cancer cells. In the same line, we designed new conjugate systems where delocalized cationic moiety delivers a photosensitizer to mitochondria. To prove our concept, two prototype conjugates (TPP-Rh and TPP-AO) were prepared using two cationic dyes (Rhodamine and Acridine Orange) and a photosensitizer (tetraphenylporphyrin, TPP). The two conjugates generated singlet oxygen quite well. Interestingly, the two conjugates showed higher cellular uptake by mover than 8 times than TPP-OH as well as higher phototoxicity. In particular, TPP-Rh showed closer localization pattern to mitochondria than TPP-OH.",
keywords = "acridine orange, Conjugate, mitochondria, rhodamine",
author = "Youngjae You and Ngen, \{Ethel J.\} and Pallavi Rajaputra",
year = "2009",
doi = "10.1117/12.823010",
language = "English",
isbn = "9780819476609",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "12th World Congress of the International Photodynamic Association - Photodynamic Therapy",
note = "12th World Congress of the International Photodynamic Association - Photodynamic Therapy: Back to the Future ; Conference date: 11-06-2009 Through 15-06-2009",
}