Conformational analysis of synthetic androgens. IV. 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate

Douglas C. Rohrer; William L. Duax; Manfred E. Wolff

doi:10.1016/S0039-128X(79)80020-3

Conformational analysis of synthetic androgens. IV. 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate

Douglas C. Rohrer
, William L. Duax
, Manfred E. Wolff

Department of Structural Biology

Hauptman-Woodward Medical Research Institute, Inc.
University of California at San Francisco

Research output: Contribution to journal › Article › peer-review

Abstract

The crystal and molecular structure of 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate has been determined to evaluate the conformational importance of the intact steroid nucleus. The resulting tricyclic compound retains nearly the same steric profile for the remainder of the molecule when compared to the structures of dihydrotestosterone derivatives with intact A-rings. This may help to explain why these types of molecules retain a significant level of androgenic activity.

Original language	English
Pages (from-to)	589-595
Number of pages	7
Journal	Steroids
Volume	34
Issue number	5
DOIs	https://doi.org/10.1016/S0039-128X(79)80020-3
State	Published - Nov 1979

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title = "Conformational analysis of synthetic androgens. IV. 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate",

abstract = "The crystal and molecular structure of 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate has been determined to evaluate the conformational importance of the intact steroid nucleus. The resulting tricyclic compound retains nearly the same steric profile for the remainder of the molecule when compared to the structures of dihydrotestosterone derivatives with intact A-rings. This may help to explain why these types of molecules retain a significant level of androgenic activity.",

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AU - Wolff, Manfred E.

PY - 1979/11

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N2 - The crystal and molecular structure of 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate has been determined to evaluate the conformational importance of the intact steroid nucleus. The resulting tricyclic compound retains nearly the same steric profile for the remainder of the molecule when compared to the structures of dihydrotestosterone derivatives with intact A-rings. This may help to explain why these types of molecules retain a significant level of androgenic activity.

AB - The crystal and molecular structure of 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate has been determined to evaluate the conformational importance of the intact steroid nucleus. The resulting tricyclic compound retains nearly the same steric profile for the remainder of the molecule when compared to the structures of dihydrotestosterone derivatives with intact A-rings. This may help to explain why these types of molecules retain a significant level of androgenic activity.

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DO - 10.1016/S0039-128X(79)80020-3

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AN - SCOPUS:0018644352

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ER -

Conformational analysis of synthetic androgens. IV. 1,2-seco-A-bisnor-5α-androstan-17β-ol acetate

Abstract

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