Complement activity in middle ear effusions

J. M. Bernstein; H. A. Schenkein; R. J. Genco; W. R. Bartholomew

Complement activity in middle ear effusions

J. M. Bernstein
, H. A. Schenkein
, R. J. Genco
, W. R. Bartholomew

Department of Otolaryngology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Evidence for complement utilization in middle ear fluids (MEF) from patients with otitis media with effusion was sought. It was found that cleavage products of C3, C4 and Factor B could be demonstrated immunochemically in MEF, and that native C3 was present in much lower concentrations than other proteins, relative to their serum concentrations. Haemolytic assays for C1-C5 showed that early complement components are inactivated in MEF. Potential mechanisms for complement utilization in MEF are discussed.

Original language	English
Pages (from-to)	340-346
Number of pages	7
Journal	Clinical and Experimental Immunology
Volume	33
Issue number	2
State	Published - 1978

Cite this

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title = "Complement activity in middle ear effusions",

abstract = "Evidence for complement utilization in middle ear fluids (MEF) from patients with otitis media with effusion was sought. It was found that cleavage products of C3, C4 and Factor B could be demonstrated immunochemically in MEF, and that native C3 was present in much lower concentrations than other proteins, relative to their serum concentrations. Haemolytic assays for C1-C5 showed that early complement components are inactivated in MEF. Potential mechanisms for complement utilization in MEF are discussed.",

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journal = "Clinical and Experimental Immunology",

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T1 - Complement activity in middle ear effusions

AU - Bernstein, J. M.

AU - Schenkein, H. A.

AU - Genco, R. J.

AU - Bartholomew, W. R.

PY - 1978

Y1 - 1978

N2 - Evidence for complement utilization in middle ear fluids (MEF) from patients with otitis media with effusion was sought. It was found that cleavage products of C3, C4 and Factor B could be demonstrated immunochemically in MEF, and that native C3 was present in much lower concentrations than other proteins, relative to their serum concentrations. Haemolytic assays for C1-C5 showed that early complement components are inactivated in MEF. Potential mechanisms for complement utilization in MEF are discussed.

AB - Evidence for complement utilization in middle ear fluids (MEF) from patients with otitis media with effusion was sought. It was found that cleavage products of C3, C4 and Factor B could be demonstrated immunochemically in MEF, and that native C3 was present in much lower concentrations than other proteins, relative to their serum concentrations. Haemolytic assays for C1-C5 showed that early complement components are inactivated in MEF. Potential mechanisms for complement utilization in MEF are discussed.

UR - https://www.scopus.com/pages/publications/0018082696

M3 - Article

C2 - 102478

AN - SCOPUS:0018082696

SN - 0009-9104

VL - 33

SP - 340

EP - 346

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

IS - 2

ER -

Complement activity in middle ear effusions

Abstract

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