@inproceedings{084356dafb0f4595b53d31d91e27dd8d,
title = "Comparing administration route in rats with streptozocin-induced diabetes and inhibition of myoblast growth of vanadium [V(III), V(IV), and V(V)] dipicolinic acid complexes",
abstract = "The V(V) dipicolinic acid complex was the most potent complex in two administration routes for reducing diabetic hyperglycemia or hyperlipidemia. After V(V) dipic treatment in both routes an inverse correlation of the blood/serum vanadium pool versus blood/plasma glucose pool was found. This is the first vanadium complex to show such a correlation in any diabetic population. The distribution in blood of V(V) and V (IV) dipic complexes was best modeled with a 2compartment model after acute administration. Only the V(III) and V(V) dipic complexes stimulated myoblast growth at 1 μM complex, while all complexes inhibited growth at higher concentrations. These experiments show that the oxidation state of the vanadium in dipic complexes affects biological efficacy and that processing of the V(V) dipic complex is different fom that of the lower oxidation states. These results also show that effects of vanadium complexes on rat myoblasts are similar to those observed in diabetic animals administered compounds intraperitoneally.",
author = "Willsky, \{Gail R.\} and Godzalla, \{Michael E.\} and Kostyniak, \{Paul J.\} and Chi, \{Lai Har\} and Rohit Gupta and Yuen, \{Violet G.\} and McNeill, \{John H.\} and Mohammad Mahroof-Tahir and Smee, \{Jason J.\} and Luqin Yang and Aaron Lobernick and Shari Watson and Crans, \{Debbie C.\}",
year = "2007",
language = "English",
isbn = "0841274460",
series = "ACS Symposium Series",
pages = "93--109",
editor = "Kenneth Kustin and Joao Pessoa and Debbie Crans",
booktitle = "Vanadium",
}