Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine

E. Popova-Kuznetsova; G. Tikhonowski; A. A. Popov; V. R. Duflot; S. M. Deyev; S. M. Klimentov; I. N. Zavestovskaya; P. N. Prasad; A. V. Kabashin

doi:10.1117/12.2551432

Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine

E. Popova-Kuznetsova
, G. Tikhonowski
, A. A. Popov
, V. R. Duflot
, S. M. Deyev
, S. M. Klimentov
, I. N. Zavestovskaya
, P. N. Prasad
, A. V. Kabashin

Chemistry

Moscow Engineering Physics Institute
Karpov Institute of Physical Chemistry
Russian Academy of Sciences
P.N. Lebedev Physical Institute of the Russian Academy of Sciences
LP3

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of ¹⁵³Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.

Original language	English
Title of host publication	Synthesis and Photonics of Nanoscale Materials XVII
Editors	Jan J. Dubowski, David B. Geohegan, Andrei V. Kabashin
Publisher	SPIE
ISBN (Electronic)	9781510633018
DOIs	https://doi.org/10.1117/12.2551432
State	Published - 2020
Event	Synthesis and Photonics of Nanoscale Materials XVII 2020 - San Francisco, United States Duration: Feb 1 2020 → Feb 4 2020

Publication series

Name	Proceedings of SPIE - The International Society for Optical Engineering
Volume	11269
ISSN (Print)	0277-786X
ISSN (Electronic)	1996-756X

Conference

Conference	Synthesis and Photonics of Nanoscale Materials XVII 2020
Country/Territory	United States
City	San Francisco
Period	02/1/20 → 02/4/20

Keywords

Femtosecond laser ablation and fragmentation in Water
Nuclear nanomedicine
Sm nanoparticles

Access to Document

10.1117/12.2551432

Cite this

Popova-Kuznetsova, E., Tikhonowski, G., Popov, A. A., Duflot, V. R., Deyev, S. M., Klimentov, S. M., Zavestovskaya, I. N., Prasad, P. N., & Kabashin, A. V. (2020). Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine. In J. J. Dubowski, D. B. Geohegan, & A. V. Kabashin (Eds.), Synthesis and Photonics of Nanoscale Materials XVII Article 1126904 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11269). SPIE. https://doi.org/10.1117/12.2551432

Popova-Kuznetsova, E. ; Tikhonowski, G. ; Popov, A. A. et al. / Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine. Synthesis and Photonics of Nanoscale Materials XVII. editor / Jan J. Dubowski ; David B. Geohegan ; Andrei V. Kabashin. SPIE, 2020. (Proceedings of SPIE - The International Society for Optical Engineering).

@inproceedings{1c08c80ae4b14d468249ec1770e364f0,

title = "Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine",

abstract = "Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of 153Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.",

keywords = "Femtosecond laser ablation and fragmentation in Water, Nuclear nanomedicine, Sm nanoparticles",

author = "E. Popova-Kuznetsova and G. Tikhonowski and Popov, \{A. A.\} and Duflot, \{V. R.\} and Deyev, \{S. M.\} and Klimentov, \{S. M.\} and Zavestovskaya, \{I. N.\} and Prasad, \{P. N.\} and Kabashin, \{A. V.\}",

note = "Publisher Copyright: {\textcopyright} 2020 SPIE.; Synthesis and Photonics of Nanoscale Materials XVII 2020 ; Conference date: 01-02-2020 Through 04-02-2020",

year = "2020",

doi = "10.1117/12.2551432",

language = "English",

series = "Proceedings of SPIE - The International Society for Optical Engineering",

publisher = "SPIE",

editor = "Dubowski, \{Jan J.\} and Geohegan, \{David B.\} and Kabashin, \{Andrei V.\}",

booktitle = "Synthesis and Photonics of Nanoscale Materials XVII",

address = "United States",

}

Popova-Kuznetsova, E, Tikhonowski, G, Popov, AA, Duflot, VR, Deyev, SM, Klimentov, SM, Zavestovskaya, IN, Prasad, PN & Kabashin, AV 2020, Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine. in JJ Dubowski, DB Geohegan & AV Kabashin (eds), Synthesis and Photonics of Nanoscale Materials XVII., 1126904, Proceedings of SPIE - The International Society for Optical Engineering, vol. 11269, SPIE, Synthesis and Photonics of Nanoscale Materials XVII 2020, San Francisco, United States, 02/1/20. https://doi.org/10.1117/12.2551432

Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine. / Popova-Kuznetsova, E.; Tikhonowski, G.; Popov, A. A. et al.
Synthesis and Photonics of Nanoscale Materials XVII. ed. / Jan J. Dubowski; David B. Geohegan; Andrei V. Kabashin. SPIE, 2020. 1126904 (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 11269).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine

AU - Popova-Kuznetsova, E.

AU - Tikhonowski, G.

AU - Popov, A. A.

AU - Duflot, V. R.

AU - Deyev, S. M.

AU - Klimentov, S. M.

AU - Zavestovskaya, I. N.

AU - Prasad, P. N.

AU - Kabashin, A. V.

PY - 2020

Y1 - 2020

N2 - Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of 153Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.

AB - Nanotechnology promises a major improvement of efficacy of nuclear medicine by targeted delivery of radioactive agents to tumors, but this approach still needs novel efficient nanoformulations to maximize diagnostic and therapeutic functions. Here, we present a two-step method of laser ablation and fragmentation in water to produce non-radioactive 152Sm-enriched samarium oxide nanoparticles (Sm NPs), which can be converted to radioactive form of 153Sm beta-emitters by neutron capture reaction. We found that laser ablation in deionized water leads to the formation of NPs having diverse morphology and broad size dispersion. To improve size characteristics of formed NPs, we applied additional femtosecond laser fragmentation step, which made possible a good control of mean NPs size under a drastic narrowing of size dispersion, and the spherical shape of formed NPs. Obtained colloidal solutions of Sm NPs were stable for several weeks after the synthesis. The formed NPs present a very promising object for nuclear nanomedicine.

KW - Femtosecond laser ablation and fragmentation in Water

KW - Nuclear nanomedicine

KW - Sm nanoparticles

UR - https://www.scopus.com/pages/publications/85083294687

U2 - 10.1117/12.2551432

DO - 10.1117/12.2551432

M3 - Conference contribution

AN - SCOPUS:85083294687

T3 - Proceedings of SPIE - The International Society for Optical Engineering

BT - Synthesis and Photonics of Nanoscale Materials XVII

A2 - Dubowski, Jan J.

A2 - Geohegan, David B.

A2 - Kabashin, Andrei V.

PB - SPIE

T2 - Synthesis and Photonics of Nanoscale Materials XVII 2020

Y2 - 1 February 2020 through 4 February 2020

ER -

Popova-Kuznetsova E, Tikhonowski G, Popov AA, Duflot VR, Deyev SM, Klimentov SM et al. Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine. In Dubowski JJ, Geohegan DB, Kabashin AV, editors, Synthesis and Photonics of Nanoscale Materials XVII. SPIE. 2020. 1126904. (Proceedings of SPIE - The International Society for Optical Engineering). doi: 10.1117/12.2551432

Colloidal samarium oxide nanoparticles prepared by femtosecond laser ablation and fragmentation for nuclear nanomedicine

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Fingerprint

Cite this