CoCEST: Cobalt(II) amide-appended paraCEST MRI contrast agents

Sarina J. Dorazio; Abiola O. Olatunde; Joseph A. Spernyak; Janet R. Morrow

doi:10.1039/c3cc45000g

CoCEST: Cobalt(II) amide-appended paraCEST MRI contrast agents

Sarina J. Dorazio
, Abiola O. Olatunde
, Joseph A. Spernyak
, Janet R. Morrow

Chemistry

SUNY Buffalo
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

The first examples of air-stable Co^II paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

Original language	English
Pages (from-to)	10025-10027
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	85
DOIs	https://doi.org/10.1039/c3cc45000g
State	Published - Oct 2013

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10.1039/c3cc45000g

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title = "CoCEST: Cobalt(II) amide-appended paraCEST MRI contrast agents",

abstract = "The first examples of air-stable CoII paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.",

author = "Dorazio, \{Sarina J.\} and Olatunde, \{Abiola O.\} and Spernyak, \{Joseph A.\} and Morrow, \{Janet R.\}",

year = "2013",

month = oct,

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language = "English",

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pages = "10025--10027",

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T2 - Cobalt(II) amide-appended paraCEST MRI contrast agents

AU - Dorazio, Sarina J.

AU - Olatunde, Abiola O.

AU - Spernyak, Joseph A.

AU - Morrow, Janet R.

PY - 2013/10

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N2 - The first examples of air-stable CoII paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

AB - The first examples of air-stable CoII paraCEST MRI contrast agents are reported. Amide NH protons on the complexes give rise to CEST peaks that are shifted up to 112 ppm from the bulk water resonance. One complex has multiple CEST peaks that may be useful for ratiometric mapping of pH.

UR - https://www.scopus.com/pages/publications/84885138795

U2 - 10.1039/c3cc45000g

DO - 10.1039/c3cc45000g

M3 - Article

C2 - 24045271

AN - SCOPUS:84885138795

SN - 1359-7345

VL - 49

SP - 10025

EP - 10027

JO - Chemical Communications

JF - Chemical Communications

IS - 85

ER -

CoCEST: Cobalt(II) amide-appended paraCEST MRI contrast agents

Abstract

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