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Clinical and preclinical bariatric surgery approaches to studying obesity

  • Women and Children's Hospital of Buffalo
  • SUNY Buffalo
  • Tufts University

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Obesity is the largest global public health epidemic. The benefits of bariatric surgery are well established, and bariatric surgery remains as the most common and effective procedure to treat obesity. The present review examined bariatric surgery procedures in humans as well as in rodent models. In addition, we examined different neuroimaging methods of assessing the effects of bariatric surgery on brain chemistry and function. This is especially important given the expanded understanding of gut-brain neurophysiology in studying obesity and ingestive behavior. In addition, given the underlying similarities in vulnerabilities and mechanisms between obesity and drug addiction, the future use of multiple techniques (i.e., imaging, genetics, psychosocial information) could all be utilized in a precision medicine approach to improve long-term patient outcomes.

Original languageEnglish
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages187-201
Number of pages15
DOIs
StatePublished - 2021

Publication series

NameNeuromethods
Volume161
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

Keywords

  • Addiction
  • Autoradiography
  • Bariatric surgery
  • Ingestive behavior
  • Neuroimaging
  • Obesity
  • Positron-emission tomography
  • Reward deficiency syndrome

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