Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

Moses Bio; Gregory Nkepang; Youngjae You

doi:10.1039/c2cc32373g

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

Moses Bio
, Gregory Nkepang
, Youngjae You

Pharmaceutical Sciences

University of Oklahoma

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

“Click and Photo-unclick Chemistry” of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.

Original language	English
Pages (from-to)	6517-6519
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	52
DOIs	https://doi.org/10.1039/c2cc32373g
State	Published - Jun 6 2012

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title = "Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release",

abstract = "“Click and Photo-unclick Chemistry” of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.",

author = "Moses Bio and Gregory Nkepang and Youngjae You",

year = "2012",

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doi = "10.1039/c2cc32373g",

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AU - Bio, Moses

AU - Nkepang, Gregory

AU - You, Youngjae

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N2 - “Click and Photo-unclick Chemistry” of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.

AB - “Click and Photo-unclick Chemistry” of aminoacrylates is proposed for a new photo-labile linker. Adducts are built in 2 steps with good yields and cleaved rapidly by tissue penetrable visible light (690 nm) with a photosensitizer. Facile synthesis, release of mother drug, and stability and cleavage in medium are demonstrated.

UR - https://www.scopus.com/pages/publications/84862218873

U2 - 10.1039/c2cc32373g

DO - 10.1039/c2cc32373g

M3 - Article

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VL - 48

SP - 6517

EP - 6519

JO - Chemical Communications

JF - Chemical Communications

IS - 52

ER -

Click and photo-unclick chemistry of aminoacrylate for visible light-triggered drug release

Abstract

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