TY - JOUR
T1 - Chronic recreational physical inactivity and epithelial ovarian cancer risk
T2 - Evidence from the ovarian cancer association consortium
AU - Cannioto, Rikki
AU - LaMonte, Michael J.
AU - Risch, Harvey A.
AU - Hong, Chi Chen
AU - Sucheston-Campbell, Lara E.
AU - Eng, Kevin H.
AU - Szender, J. Brian
AU - Chang-Claude, Jenny
AU - Schmalfeldt, Barbara
AU - Klapdor, Ruediger
AU - Gower, Emily
AU - Minlikeeva, Albina N.
AU - Zirpoli, Gary R.
AU - Bandera, Elisa V.
AU - Berchuck, Andrew
AU - Cramer, Daniel
AU - Doherty, Jennifer A.
AU - Edwards, Robert P.
AU - Fridley, Brooke L.
AU - Goode, Ellen L.
AU - Goodman, Marc T.
AU - Hogdall, Estrid
AU - Hosono, Satoyo
AU - Jensen, Allan
AU - Jordan, Susan
AU - Kjaer, Susanne K.
AU - Matsuo, Keitaro
AU - Ness, Roberta B.
AU - Olsen, Catherine M.
AU - Olson, Sara H.
AU - Pearce, Celeste Leigh
AU - Pike, Malcolm C.
AU - Rossing, Mary Anne
AU - Szamreta, Elizabeth A.
AU - Thompson, Pamela J.
AU - Tseng, Chiu Chen
AU - Vierkant, Robert A.
AU - Webb, Penelope M.
AU - Wentzensen, Nicolas
AU - Wicklund, Kristine G.
AU - Winham, Stacey J.
AU - Wu, Anna H.
AU - Modugno, Francesmary
AU - Schildkraut, Joellen M.
AU - Terry, Kathryn L.
AU - Kelemen, Linda E.
AU - Moysich, Kirsten B.
N1 - Publisher Copyright:
© 2016 American Association for Cancer Research.
PY - 2016/7
Y1 - 2016/7
N2 - Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.
AB - Background: Despite a large body of literature evaluating the association between recreational physical activity and epithelial ovarian cancer (EOC) risk, the extant evidence is inconclusive, and little is known about the independent association between recreational physical inactivity and EOC risk. We conducted a pooled analysis of nine studies from the Ovarian Cancer Association Consortium to investigate the association between chronic recreational physical inactivity and EOC risk. Methods: In accordance with the 2008 Physical Activity Guidelines for Americans, women reporting no regular, weekly recreational physical activity were classified as inactive. Multivariable logistic regression was utilized to estimate the ORs and 95% confidence intervals (CI) for the association between inactivity and EOC risk overall and by subgroups based upon histotype, menopausal status, race, and body mass index. Results: The current analysis included data from 8,309 EOC patients and 12,612 controls. We observed a significant positive association between inactivity and EOC risk (OR = 1.34; 95% CI, 1.14-1.57), and similar associations were observed for each histotype. Conclusions: In this large pooled analysis examining the association between recreational physical inactivity and EOC risk, we observed consistent evidence of an association between chronic inactivity and all EOC histotypes. Impact: These data add to the growing body of evidence suggesting that inactivity is an independent risk factor for cancer. If the apparent association between inactivity and EOC risk is substantiated, additional work via targeted interventions should be pursued to characterize the dose of activity required to mitigate the risk of this highly fatal disease.
UR - https://www.scopus.com/pages/publications/84977071152
U2 - 10.1158/1055-9965.EPI-15-1330
DO - 10.1158/1055-9965.EPI-15-1330
M3 - Article
C2 - 27197285
AN - SCOPUS:84977071152
SN - 1055-9965
VL - 25
SP - 1114
EP - 1124
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 7
ER -