Chronic ethanol exposure potentiates muscarinic receptor and α2-adrenoceptor-mediated inhibition of cAMP accumulation in PC 12 cells

Won Ki Kim; Mark H. Hawthorn; Richard A. Rabin

doi:10.1016/0922-4106(93)90141-U

Chronic ethanol exposure potentiates muscarinic receptor and α₂-adrenoceptor-mediated inhibition of cAMP accumulation in PC 12 cells

Won Ki Kim
, Mark H. Hawthorn
, Richard A. Rabin

Pharmacology and Toxicology

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The effects of ethanol on receptor-mediated inhibition of cAMP production were investigated in PC 12 cells. The in vitro addition of ethanol enhanced N-ethylcarboxyadenosine (NECA)-stimulated cAMP production without altering the inhibitory action of carbachol or epinephrine. A 4 day exposure of PC 12 cells to ethanol decreased the stimulation of cAMP production by NECA, but increased the inhibition of NECA-stimulated cAMP production by carbachol and epinephrine.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	247
Issue number	1
DOIs	https://doi.org/10.1016/0922-4106(93)90141-U
State	Published - Sep 15 1993

Keywords

cAMP
Ethanol
Muscarinic acetylcholine receptor
α-Adrenoceptor

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10.1016/0922-4106(93)90141-U

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title = "Chronic ethanol exposure potentiates muscarinic receptor and α2-adrenoceptor-mediated inhibition of cAMP accumulation in PC 12 cells",

abstract = "The effects of ethanol on receptor-mediated inhibition of cAMP production were investigated in PC 12 cells. The in vitro addition of ethanol enhanced N-ethylcarboxyadenosine (NECA)-stimulated cAMP production without altering the inhibitory action of carbachol or epinephrine. A 4 day exposure of PC 12 cells to ethanol decreased the stimulation of cAMP production by NECA, but increased the inhibition of NECA-stimulated cAMP production by carbachol and epinephrine.",

keywords = "cAMP, Ethanol, Muscarinic acetylcholine receptor, α-Adrenoceptor",

author = "Kim, \{Won Ki\} and Hawthorn, \{Mark H.\} and Rabin, \{Richard A.\}",

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T1 - Chronic ethanol exposure potentiates muscarinic receptor and α2-adrenoceptor-mediated inhibition of cAMP accumulation in PC 12 cells

AU - Kim, Won Ki

AU - Hawthorn, Mark H.

AU - Rabin, Richard A.

PY - 1993/9/15

Y1 - 1993/9/15

N2 - The effects of ethanol on receptor-mediated inhibition of cAMP production were investigated in PC 12 cells. The in vitro addition of ethanol enhanced N-ethylcarboxyadenosine (NECA)-stimulated cAMP production without altering the inhibitory action of carbachol or epinephrine. A 4 day exposure of PC 12 cells to ethanol decreased the stimulation of cAMP production by NECA, but increased the inhibition of NECA-stimulated cAMP production by carbachol and epinephrine.

AB - The effects of ethanol on receptor-mediated inhibition of cAMP production were investigated in PC 12 cells. The in vitro addition of ethanol enhanced N-ethylcarboxyadenosine (NECA)-stimulated cAMP production without altering the inhibitory action of carbachol or epinephrine. A 4 day exposure of PC 12 cells to ethanol decreased the stimulation of cAMP production by NECA, but increased the inhibition of NECA-stimulated cAMP production by carbachol and epinephrine.

KW - cAMP

KW - Ethanol

KW - Muscarinic acetylcholine receptor

KW - α-Adrenoceptor

UR - https://www.scopus.com/pages/publications/0027183062

U2 - 10.1016/0922-4106(93)90141-U

DO - 10.1016/0922-4106(93)90141-U

M3 - Article

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AN - SCOPUS:0027183062

SN - 0922-4106

VL - 247

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JO - European Journal of Pharmacology: Molecular Pharmacology

JF - European Journal of Pharmacology: Molecular Pharmacology

IS - 1

ER -

Chronic ethanol exposure potentiates muscarinic receptor and α₂-adrenoceptor-mediated inhibition of cAMP accumulation in PC 12 cells

Abstract

Keywords

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