Chlamydia trachomatis serology in women with and without ovarian cancer

Roberta B. Ness; Caixia Shen; Debra Bass; Carlynn Jackson; Kristen Moysich; Robert Edwards; Robert C. Brunham

doi:10.1155/2008/219672

Chlamydia trachomatis serology in women with and without ovarian cancer

Roberta B. Ness
, Caixia Shen
, Debra Bass
, Carlynn Jackson
, Kristen Moysich
, Robert Edwards
, Robert C. Brunham

Department of Epidemiology and Environmental Health

University of Texas Health Science Center at Houston
University of British Columbia
University of Pittsburgh

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4-0.9). These data do not support our earlier finding of elevated titers for antibodies to C. trachomatis among women with ovarian cancer.

Original language	English
Article number	219672
Journal	Infectious Diseases in Obstetrics and Gynecology
Volume	2008
DOIs	https://doi.org/10.1155/2008/219672
State	Published - 2008

Access to Document

10.1155/2008/219672

Cite this

@article{9cae980e6826482cb6cef355f66cddc2,

title = "Chlamydia trachomatis serology in women with and without ovarian cancer",

abstract = "Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95\% CI 0.4-0.9). These data do not support our earlier finding of elevated titers for antibodies to C. trachomatis among women with ovarian cancer.",

author = "Ness, \{Roberta B.\} and Caixia Shen and Debra Bass and Carlynn Jackson and Kristen Moysich and Robert Edwards and Brunham, \{Robert C.\}",

year = "2008",

doi = "10.1155/2008/219672",

language = "English",

volume = "2008",

journal = "Infectious Diseases in Obstetrics and Gynecology",

issn = "1064-7449",

publisher = "John Wiley and Sons Inc",

}

TY - JOUR

T1 - Chlamydia trachomatis serology in women with and without ovarian cancer

AU - Ness, Roberta B.

AU - Shen, Caixia

AU - Bass, Debra

AU - Jackson, Carlynn

AU - Moysich, Kristen

AU - Edwards, Robert

AU - Brunham, Robert C.

PY - 2008

Y1 - 2008

N2 - Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4-0.9). These data do not support our earlier finding of elevated titers for antibodies to C. trachomatis among women with ovarian cancer.

AB - Pelvic inflammation has been implicated in the genesis of ovarian cancer. We conducted serologic measurements of Chlamydia trachomatis antibodies as a surrogate marker of chlamydial pelvic inflammatory disease. Women with ovarian cancer (n = 521) and population-based controls (n = 766) were tested. IgG antibodies to serovar D of chlamydia elementary bodies (EBs) were detected using an ELISA assay. The odds of having ovarian cancer among women with the highest titers (≥0.40 OD units) were 0.6 (95% CI 0.4-0.9). These data do not support our earlier finding of elevated titers for antibodies to C. trachomatis among women with ovarian cancer.

UR - https://www.scopus.com/pages/publications/58149159845

U2 - 10.1155/2008/219672

DO - 10.1155/2008/219672

M3 - Article

C2 - 19125176

AN - SCOPUS:58149159845

SN - 1064-7449

VL - 2008

JO - Infectious Diseases in Obstetrics and Gynecology

JF - Infectious Diseases in Obstetrics and Gynecology

M1 - 219672

ER -

Chlamydia trachomatis serology in women with and without ovarian cancer

Abstract

Access to Document

Other files and links

Fingerprint

Cite this