Chiral indoline synthesis via enantioselective intramolecular copper-catalyzed alkene hydroamination

Benjamin W. Turnpenny; Kiante L. Hyman; Sherry R. Chemler

doi:10.1021/om300744m

Chiral indoline synthesis via enantioselective intramolecular copper-catalyzed alkene hydroamination

Benjamin W. Turnpenny
, Kiante L. Hyman
, Sherry R. Chemler

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

An enantioselective copper-catalyzed hydroamination/cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methylindolines in up to 90% ee.

Original language	English
Pages (from-to)	7819-7822
Number of pages	4
Journal	Organometallics
Volume	31
Issue number	22
DOIs	https://doi.org/10.1021/om300744m
State	Published - Nov 26 2012

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title = "Chiral indoline synthesis via enantioselective intramolecular copper-catalyzed alkene hydroamination",

abstract = "An enantioselective copper-catalyzed hydroamination/cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methylindolines in up to 90\% ee.",

author = "Turnpenny, \{Benjamin W.\} and Hyman, \{Kiante L.\} and Chemler, \{Sherry R.\}",

year = "2012",

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T1 - Chiral indoline synthesis via enantioselective intramolecular copper-catalyzed alkene hydroamination

AU - Turnpenny, Benjamin W.

AU - Hyman, Kiante L.

AU - Chemler, Sherry R.

PY - 2012/11/26

Y1 - 2012/11/26

N2 - An enantioselective copper-catalyzed hydroamination/cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methylindolines in up to 90% ee.

AB - An enantioselective copper-catalyzed hydroamination/cyclization of N-sulfonyl-2-allylanilines for the synthesis of chiral 2-methylindolines is reported. Chiral 2-methylindolines are important subunits in drugs and bioactive compounds. This method provides chiral N-sulfonyl-2-methylindolines in up to 90% ee.

UR - https://www.scopus.com/pages/publications/84870052619

U2 - 10.1021/om300744m

DO - 10.1021/om300744m

M3 - Article

AN - SCOPUS:84870052619

SN - 0276-7333

VL - 31

SP - 7819

EP - 7822

JO - Organometallics

JF - Organometallics

IS - 22

ER -

Chiral indoline synthesis via enantioselective intramolecular copper-catalyzed alkene hydroamination

Abstract

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