Cellular quiescence caused by the Mdm2 inhibitor nutlin-3a

Lioubov G. Korotchkina; Zoya N. Demidenko; Andrei V. Gudkov; Mikhail V. Blagosklonny

doi:10.4161/cc.8.22.10121

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3a

Lioubov G. Korotchkina
, Zoya N. Demidenko
, Andrei V. Gudkov
, Mikhail V. Blagosklonny

Roswell Park - Cell Stress and Biophysical Oncology

Roswell Park Cancer Institute
Oncotarget

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in Ht1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).

Original language	English
Pages (from-to)	3777-3781
Number of pages	5
Journal	Cell Cycle
Volume	8
Issue number	22
DOIs	https://doi.org/10.4161/cc.8.22.10121
State	Published - Nov 15 2009

Keywords

Cell cycle
p21
p53
Quiescence
Senescence

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10.4161/cc.8.22.10121

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title = "Cellular quiescence caused by the Mdm2 inhibitor nutlin-3a",

abstract = "Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in Ht1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).",

keywords = "Cell cycle, p21, p53, Quiescence, Senescence",

author = "Korotchkina, \{Lioubov G.\} and Demidenko, \{Zoya N.\} and Gudkov, \{Andrei V.\} and Blagosklonny, \{Mikhail V.\}",

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AU - Korotchkina, Lioubov G.

AU - Demidenko, Zoya N.

AU - Gudkov, Andrei V.

AU - Blagosklonny, Mikhail V.

PY - 2009/11/15

Y1 - 2009/11/15

N2 - Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in Ht1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).

AB - Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in Ht1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhibitor nutlin-3a induced p53 but, unexpectedly, caused quiescence (reversible arrest) with a small cell morphology. We discuss that Mdm antagonists could be used in combination with chemotherapy to reversibly arrest normal cells, thus protecting them during chemotherapy of cancer (cyclotherapy).

KW - Cell cycle

KW - p21

KW - p53

KW - Quiescence

KW - Senescence

UR - https://www.scopus.com/pages/publications/70449906988

U2 - 10.4161/cc.8.22.10121

DO - 10.4161/cc.8.22.10121

M3 - Article

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AN - SCOPUS:70449906988

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SP - 3777

EP - 3781

JO - Cell Cycle

JF - Cell Cycle

IS - 22

ER -

Cellular quiescence caused by the Mdm2 inhibitor nutlin-3a

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Keywords

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