Carrier-mediated transport of urate by chicken (Gallus domesticus) renal brush-border membrane vesicles

Shiu Ming Kuo; Richard E. Austic

doi:10.1016/0300-9629(87)90366-5

Carrier-mediated transport of urate by chicken (Gallus domesticus) renal brush-border membrane vesicles

Shiu Ming Kuo
, Richard E. Austic

Nutrition

Cornell University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

1. 1. Urate is transported by an anion exchange system in chicken renal brush-border membrane vesicles. An outward chloride gradient stimulates an overshoot in urate uptake. 2. 2. The anion exchanger is similar to those described for the kidneys of rats and dogs except that the chicken exchanger has a higher specificity for urate. 3. 3. p-Aminohippurate has only a weak affinity, if any, for the urate exchanger. 4. 4. There were no apparent qualitative differences in urate transport between brush-border membrane vesicles from genetically normouricemic and hyperuricemic chickens.

Original language	English
Pages (from-to)	587-595
Number of pages	9
Journal	Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology
Volume	87
Issue number	3
DOIs	https://doi.org/10.1016/0300-9629(87)90366-5
State	Published - 1987

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title = "Carrier-mediated transport of urate by chicken (Gallus domesticus) renal brush-border membrane vesicles",

abstract = "1. 1. Urate is transported by an anion exchange system in chicken renal brush-border membrane vesicles. An outward chloride gradient stimulates an overshoot in urate uptake. 2. 2. The anion exchanger is similar to those described for the kidneys of rats and dogs except that the chicken exchanger has a higher specificity for urate. 3. 3. p-Aminohippurate has only a weak affinity, if any, for the urate exchanger. 4. 4. There were no apparent qualitative differences in urate transport between brush-border membrane vesicles from genetically normouricemic and hyperuricemic chickens.",

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AU - Austic, Richard E.

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N2 - 1. 1. Urate is transported by an anion exchange system in chicken renal brush-border membrane vesicles. An outward chloride gradient stimulates an overshoot in urate uptake. 2. 2. The anion exchanger is similar to those described for the kidneys of rats and dogs except that the chicken exchanger has a higher specificity for urate. 3. 3. p-Aminohippurate has only a weak affinity, if any, for the urate exchanger. 4. 4. There were no apparent qualitative differences in urate transport between brush-border membrane vesicles from genetically normouricemic and hyperuricemic chickens.

AB - 1. 1. Urate is transported by an anion exchange system in chicken renal brush-border membrane vesicles. An outward chloride gradient stimulates an overshoot in urate uptake. 2. 2. The anion exchanger is similar to those described for the kidneys of rats and dogs except that the chicken exchanger has a higher specificity for urate. 3. 3. p-Aminohippurate has only a weak affinity, if any, for the urate exchanger. 4. 4. There were no apparent qualitative differences in urate transport between brush-border membrane vesicles from genetically normouricemic and hyperuricemic chickens.

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U2 - 10.1016/0300-9629(87)90366-5

DO - 10.1016/0300-9629(87)90366-5

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SN - 1095-6433

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JO - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

JF - Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology

IS - 3

ER -

Carrier-mediated transport of urate by chicken (Gallus domesticus) renal brush-border membrane vesicles

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