Cardiovascular disease in survivors of childhood cancer

Neha Bansal; Shahnawaz M. Amdani; Kelley K. Hutchins; Steven E. Lipshultz

doi:10.1097/MOP.0000000000000675

Cardiovascular disease in survivors of childhood cancer

Neha Bansal
, Shahnawaz M. Amdani
, Kelley K. Hutchins
, Steven E. Lipshultz

Pediatrics

Children's Hospital of Michigan
Washington University St. Louis

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A deeper understanding of the mechanisms of their cardiotoxicity reveals that there is no 'safe' dose of anthracyclines. However, certain risk factors, such as higher lifetime anthracycline cumulative doses, higher anthracycline dose rates, female sex, longer follow-up, younger age at anthracycline treatment and cardiac irradiation, are associated with more severe cardiotoxicity. We advocate the use of dexrazoxane to limit the cardiotoxic effects of anthracycline chemotherapy.

Original language	English
Pages (from-to)	628-638
Number of pages	11
Journal	Current Opinion in Pediatrics
Volume	30
Issue number	5
DOIs	https://doi.org/10.1097/MOP.0000000000000675
State	Published - 2018

Keywords

Anthracycline
Cardio-oncology
Cardiotoxicity
Childhood cancer
Survivorship

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title = "Cardiovascular disease in survivors of childhood cancer",

abstract = "A deeper understanding of the mechanisms of their cardiotoxicity reveals that there is no 'safe' dose of anthracyclines. However, certain risk factors, such as higher lifetime anthracycline cumulative doses, higher anthracycline dose rates, female sex, longer follow-up, younger age at anthracycline treatment and cardiac irradiation, are associated with more severe cardiotoxicity. We advocate the use of dexrazoxane to limit the cardiotoxic effects of anthracycline chemotherapy.",

keywords = "Anthracycline, Cardio-oncology, Cardiotoxicity, Childhood cancer, Survivorship",

author = "Neha Bansal and Amdani, \{Shahnawaz M.\} and Hutchins, \{Kelley K.\} and Lipshultz, \{Steven E.\}",

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AU - Amdani, Shahnawaz M.

AU - Hutchins, Kelley K.

AU - Lipshultz, Steven E.

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N2 - A deeper understanding of the mechanisms of their cardiotoxicity reveals that there is no 'safe' dose of anthracyclines. However, certain risk factors, such as higher lifetime anthracycline cumulative doses, higher anthracycline dose rates, female sex, longer follow-up, younger age at anthracycline treatment and cardiac irradiation, are associated with more severe cardiotoxicity. We advocate the use of dexrazoxane to limit the cardiotoxic effects of anthracycline chemotherapy.

AB - A deeper understanding of the mechanisms of their cardiotoxicity reveals that there is no 'safe' dose of anthracyclines. However, certain risk factors, such as higher lifetime anthracycline cumulative doses, higher anthracycline dose rates, female sex, longer follow-up, younger age at anthracycline treatment and cardiac irradiation, are associated with more severe cardiotoxicity. We advocate the use of dexrazoxane to limit the cardiotoxic effects of anthracycline chemotherapy.

KW - Anthracycline

KW - Cardio-oncology

KW - Cardiotoxicity

KW - Childhood cancer

KW - Survivorship

UR - https://www.scopus.com/pages/publications/85056496846

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DO - 10.1097/MOP.0000000000000675

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JO - Current Opinion in Pediatrics

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IS - 5

ER -

Cardiovascular disease in survivors of childhood cancer

Abstract

Keywords

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