Cardiac mechanosensitivity and stretch-activated ion channels

G. C.L. Bett; F. Sachs

doi:10.1016/S1050-1738(96)00119-3

Cardiac mechanosensitivity and stretch-activated ion channels

G. C.L. Bett
, F. Sachs

Department of Obstetrics and Gynecology

SUNY Buffalo

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart, MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs.

Original language	English
Pages (from-to)	4-8
Number of pages	5
Journal	Trends in Cardiovascular Medicine
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/S1050-1738(96)00119-3
State	Published - Jan 1997

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title = "Cardiac mechanosensitivity and stretch-activated ion channels",

abstract = "Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart, MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs.",

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AU - Bett, G. C.L.

AU - Sachs, F.

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N2 - Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart, MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs.

AB - Mechanosensitivity is a ubiquitous property of cells, and mechanosensitive ion channels (MSCs) are hypothesized to be the transducers. In the heart, MSCs are likely to account for changes in beating rate as a function of filling and for initiating stretch-induced arrhythmias (for example, following a myocardial infarction). Pharmacological agents that affect MSCs may provide a new class of antiarrhythmic drugs.

UR - https://www.scopus.com/pages/publications/0031034309

U2 - 10.1016/S1050-1738(96)00119-3

DO - 10.1016/S1050-1738(96)00119-3

M3 - Review article

AN - SCOPUS:0031034309

SN - 1050-1738

VL - 7

SP - 4

EP - 8

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 1

ER -

Cardiac mechanosensitivity and stretch-activated ion channels

Abstract

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