Captopril and Renal Insufficiency

To the Editor: Curtis et al. reported captopril-induced functional renal insufficiency in four transplant recipients with hypertension and graft-artery stenosis (Feb. 17 issue).* No such changes were observed after captopril administration in hypertensive transplant recipients without graft-artery stenosis. The authors thus suggest that captopril could be used as a diagnostic test to detect artery stenosis in hypertensive graft recipients. Our own data support their conclusion that captopril-induced renal failure in transplant recipients is suggestive of graft-artery stenosis. These data provide further evidence that in these cases the graft-artery stenosis is the cause of hypertension. Over the past two years we.