Camptodactyly: A Kindred Study

Armand Littman; Jerome W. Yates; Albert Treger

doi:10.1001/jama.1968.03150070103025

Camptodactyly: A Kindred Study

Armand Littman
, Jerome W. Yates
, Albert Treger

Department of Epidemiology and Environmental Health

VA Medical Center
University of Illinois at Chicago

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Camptodactyly is an autosomal dominant trait occurring in less than 1% of the population. We have studied an involved kindred of 71 persons through seven generations. Penetrance was variable and involvement of the right hand predominated. Prevalence rate decreased with succeeding generations, suggesting “genetic dilution” of a necessary modifier gene. Association with radio-ulnar synostosis was found in two sons of sisters, but orthopedic or biochemical associations were not confirmed, and linkage with peptic ulcer was disestablished.

Original language	English
Pages (from-to)	1565-1567
Number of pages	3
Journal	JAMA: The Journal of the American Medical Association
Volume	206
Issue number	7
DOIs	https://doi.org/10.1001/jama.1968.03150070103025
State	Published - Nov 11 1968

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AU - Treger, Albert

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N2 - Camptodactyly is an autosomal dominant trait occurring in less than 1% of the population. We have studied an involved kindred of 71 persons through seven generations. Penetrance was variable and involvement of the right hand predominated. Prevalence rate decreased with succeeding generations, suggesting “genetic dilution” of a necessary modifier gene. Association with radio-ulnar synostosis was found in two sons of sisters, but orthopedic or biochemical associations were not confirmed, and linkage with peptic ulcer was disestablished.

AB - Camptodactyly is an autosomal dominant trait occurring in less than 1% of the population. We have studied an involved kindred of 71 persons through seven generations. Penetrance was variable and involvement of the right hand predominated. Prevalence rate decreased with succeeding generations, suggesting “genetic dilution” of a necessary modifier gene. Association with radio-ulnar synostosis was found in two sons of sisters, but orthopedic or biochemical associations were not confirmed, and linkage with peptic ulcer was disestablished.

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Camptodactyly: A Kindred Study

Abstract

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