Calcium channel ligands

D. J. Triggle

doi:10.1146/annurev.pharmtox.27.1.347

Calcium channel ligands

D. J. Triggle

School of Pharmacy and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

The literature of the Ca²⁺ channel ligands has expanded dramatically in the past several years. This review concentrates primarily on developments during 1985 and 1986 and refers only selectively to the earlier literature. It covers only the Ca²⁺ channels of the plasmalemma and associated structures and does not discuss the intracellular channels of the endoplasmic and sarcoplasmic structures. We organize this review around five main areas: structure-function relationships; properties and function of binding sites; the basis of tissue selectivity; regulation of Ca²⁺ channels; and prospects for the future.

Original language	English
Pages (from-to)	347-369
Number of pages	23
Journal	Annual Review of Pharmacology and Toxicology
Volume	Vol. 27
DOIs	https://doi.org/10.1146/annurev.pharmtox.27.1.347
State	Published - 1987

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10.1146/annurev.pharmtox.27.1.347

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AB - The literature of the Ca2+ channel ligands has expanded dramatically in the past several years. This review concentrates primarily on developments during 1985 and 1986 and refers only selectively to the earlier literature. It covers only the Ca2+ channels of the plasmalemma and associated structures and does not discuss the intracellular channels of the endoplasmic and sarcoplasmic structures. We organize this review around five main areas: structure-function relationships; properties and function of binding sites; the basis of tissue selectivity; regulation of Ca2+ channels; and prospects for the future.

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JO - Annual Review of Pharmacology and Toxicology

JF - Annual Review of Pharmacology and Toxicology

ER -

Calcium channel ligands

Abstract

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