Abstract
Five of seven acutely manic patients improved significantly when taking verapamil but not placebo in a double-blind crossover study. This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium antagonists may have antimanic properties. Indirect evidence links this antimanic action to correction of a disturbance of intracellular calcium dynamics in affective disorders. However, the effectiveness of calcium antagonist drugs could also be related to some property other than interference with the action of calcium within brain neurons.
| Original language | English |
|---|---|
| Pages (from-to) | 309-320 |
| Number of pages | 12 |
| Journal | Psychiatry Research |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1986 |
Keywords
- calcium antagonists
- intracellular calcium ions
- mania
- Verapamil
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