Calcium and the muscarinic receptor

M. K. Ticku; D. J. Triggle

doi:10.1016/0306-3623(76)90049-5

Calcium and the muscarinic receptor

M. K. Ticku
, D. J. Triggle

School of Pharmacy and Pharmaceutical Sciences

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca²⁺ in excitation-contraction coupling discussed.

Original language	English
Pages (from-to)	133-140
Number of pages	8
Journal	General Pharmacology: The Vascular System
Volume	7
Issue number	2-3
DOIs	https://doi.org/10.1016/0306-3623(76)90049-5
State	Published - Aug 1976

Access to Document

10.1016/0306-3623(76)90049-5

Cite this

@article{70e51cb8985a4fac98de70293f5f7f67,

title = "Calcium and the muscarinic receptor",

abstract = "Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.",

author = "Ticku, \{M. K.\} and Triggle, \{D. J.\}",

year = "1976",

month = aug,

doi = "10.1016/0306-3623(76)90049-5",

language = "English",

volume = "7",

pages = "133--140",

journal = "General Pharmacology: The Vascular System",

issn = "0306-3623",

publisher = "Elsevier B.V.",

number = "2-3",

}

TY - JOUR

T1 - Calcium and the muscarinic receptor

AU - Ticku, M. K.

AU - Triggle, D. J.

PY - 1976/8

Y1 - 1976/8

N2 - Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.

AB - Pharmacological receptors may be viewed as composed of two linked functions, a recognition site through which the specificity and selectivity of ligand action is expressed and an amplification or catalytic site which translates the ligand-recognition site interaction into response. The successful elucidation of receptor mechanisms requires analysis of both sites. The muscarinic cholinergic receptors of guinea-pig ileal longitudinal smooth muscle will be discussed from this two function stand point and the source and utilization of Ca2+ in excitation-contraction coupling discussed.

UR - https://www.scopus.com/pages/publications/0017074728

U2 - 10.1016/0306-3623(76)90049-5

DO - 10.1016/0306-3623(76)90049-5

M3 - Article

C2 - 976732

AN - SCOPUS:0017074728

SN - 0306-3623

VL - 7

SP - 133

EP - 140

JO - General Pharmacology: The Vascular System

JF - General Pharmacology: The Vascular System

IS - 2-3

ER -

Calcium and the muscarinic receptor

Abstract

Access to Document

Other files and links

Fingerprint

Cite this