C4 polymorphism and HLA linkage: Studies in a family with hereditary C4 deficiency

Mark Ballow; Robert H. McLean; Edmond J. Yunis; Zuheir L. Awdeh; Geoffrey J. O'Neill; Mindy Einarson; Chester A. Alper

doi:10.1016/0090-1229(81)90146-X

C4 polymorphism and HLA linkage: Studies in a family with hereditary C4 deficiency

Mark Ballow
, Robert H. McLean
, Edmond J. Yunis
, Zuheir L. Awdeh
, Geoffrey J. O'Neill
, Mindy Einarson
, Chester A. Alper

Pediatrics

University of Connecticut
Dana-Farber Cancer Institute
Immune Disease Institute, Inc.
Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Family studies of C4 polymorphism and HLA linkage are presented. The proband had a lupus-like syndrome and the complete absence of hemolytic and immunochemical C4. Eleven family members covering three generations with reduced serum C4 levels had the MHC haplotype A26, Bw49, DR2, BFS, C2C, GLO-2. C4 polymorphism studies showed that the proposita was homozygous for a doubly deficient C4 haplotype, C4A^*QO,C4B^*QO and that in the family the C4 loci, C4A and C4B, were closely linked to HLA.

Original language	English
Pages (from-to)	354-360
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0090-1229(81)90146-X
State	Published - Sep 1981

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title = "C4 polymorphism and HLA linkage: Studies in a family with hereditary C4 deficiency",

abstract = "Family studies of C4 polymorphism and HLA linkage are presented. The proband had a lupus-like syndrome and the complete absence of hemolytic and immunochemical C4. Eleven family members covering three generations with reduced serum C4 levels had the MHC haplotype A26, Bw49, DR2, BFS, C2C, GLO-2. C4 polymorphism studies showed that the proposita was homozygous for a doubly deficient C4 haplotype, C4A*QO,C4B*QO and that in the family the C4 loci, C4A and C4B, were closely linked to HLA.",

author = "Mark Ballow and McLean, \{Robert H.\} and Yunis, \{Edmond J.\} and Awdeh, \{Zuheir L.\} and O'Neill, \{Geoffrey J.\} and Mindy Einarson and Alper, \{Chester A.\}",

year = "1981",

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doi = "10.1016/0090-1229(81)90146-X",

language = "English",

volume = "20",

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TY - JOUR

T1 - C4 polymorphism and HLA linkage

T2 - Studies in a family with hereditary C4 deficiency

AU - Ballow, Mark

AU - McLean, Robert H.

AU - Yunis, Edmond J.

AU - Awdeh, Zuheir L.

AU - O'Neill, Geoffrey J.

AU - Einarson, Mindy

AU - Alper, Chester A.

PY - 1981/9

Y1 - 1981/9

N2 - Family studies of C4 polymorphism and HLA linkage are presented. The proband had a lupus-like syndrome and the complete absence of hemolytic and immunochemical C4. Eleven family members covering three generations with reduced serum C4 levels had the MHC haplotype A26, Bw49, DR2, BFS, C2C, GLO-2. C4 polymorphism studies showed that the proposita was homozygous for a doubly deficient C4 haplotype, C4A*QO,C4B*QO and that in the family the C4 loci, C4A and C4B, were closely linked to HLA.

AB - Family studies of C4 polymorphism and HLA linkage are presented. The proband had a lupus-like syndrome and the complete absence of hemolytic and immunochemical C4. Eleven family members covering three generations with reduced serum C4 levels had the MHC haplotype A26, Bw49, DR2, BFS, C2C, GLO-2. C4 polymorphism studies showed that the proposita was homozygous for a doubly deficient C4 haplotype, C4A*QO,C4B*QO and that in the family the C4 loci, C4A and C4B, were closely linked to HLA.

UR - https://www.scopus.com/pages/publications/0019466914

U2 - 10.1016/0090-1229(81)90146-X

DO - 10.1016/0090-1229(81)90146-X

M3 - Article

C2 - 7341033

AN - SCOPUS:0019466914

SN - 0090-1229

VL - 20

SP - 354

EP - 360

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 3

ER -

C4 polymorphism and HLA linkage: Studies in a family with hereditary C4 deficiency

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