TY - JOUR
T1 - Borrowing information from an unidentifiable model
T2 - Guaranteed efficiency gain with a dichotomized outcome in the external data
AU - Wang, Lu
AU - Ma, Yanyuan
AU - Zhao, Jiwei
N1 - Publisher Copyright:
© The Author(s) 2026. Published by Oxford University Press on behalf of The International Biometric Society. All rights reserved. For commercial re-use, please contact [email protected] for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact [email protected]
PY - 2026/6
Y1 - 2026/6
N2 - In the era of big data, the increasing availability of diverse data sources has driven interest in analytical approaches that integrate information across sources to enhance statistical accuracy, efficiency, and scientific insights. Many existing methods assume exchangeability among data sources and often implicitly require that sources measure identical covariates or outcomes, or that the error distribution is correctly specified—assumptions that may not hold in complex real-world scenarios. This paper explores the integration of data from sources with distinct outcome scales, focusing on leveraging external data to improve statistical efficiency. Specifically, we consider a scenario where the primary dataset includes a continuous outcome, and external data provides a dichotomized version of the same outcome. We propose two novel estimators: the first estimator remains asymptotically consistent even when the error distribution is potentially misspecified, while the second estimator guarantees an efficiency gain over weighted least squares estimation that uses the primary study data alone. Theoretical properties of these estimators are rigorously derived, and extensive simulation studies are conducted to highlight their robustness and efficiency gains across various scenarios. Finally, a real-world application using the NHANES dataset demonstrates the practical utility of the proposed methods.
AB - In the era of big data, the increasing availability of diverse data sources has driven interest in analytical approaches that integrate information across sources to enhance statistical accuracy, efficiency, and scientific insights. Many existing methods assume exchangeability among data sources and often implicitly require that sources measure identical covariates or outcomes, or that the error distribution is correctly specified—assumptions that may not hold in complex real-world scenarios. This paper explores the integration of data from sources with distinct outcome scales, focusing on leveraging external data to improve statistical efficiency. Specifically, we consider a scenario where the primary dataset includes a continuous outcome, and external data provides a dichotomized version of the same outcome. We propose two novel estimators: the first estimator remains asymptotically consistent even when the error distribution is potentially misspecified, while the second estimator guarantees an efficiency gain over weighted least squares estimation that uses the primary study data alone. Theoretical properties of these estimators are rigorously derived, and extensive simulation studies are conducted to highlight their robustness and efficiency gains across various scenarios. Finally, a real-world application using the NHANES dataset demonstrates the practical utility of the proposed methods.
KW - data fusion
KW - data integration
KW - efficiency gain
KW - efficient score
KW - model misspecification
KW - unidentifiable model
UR - https://www.scopus.com/pages/publications/105037425085
U2 - 10.1093/biomtc/ujag062
DO - 10.1093/biomtc/ujag062
M3 - Article
C2 - 42053377
AN - SCOPUS:105037425085
SN - 0006-341X
VL - 82
JO - Biometrics
JF - Biometrics
IS - 2
ER -