TY - JOUR
T1 - Body mass index, waist circumference, diabetes, and risk of liver cancer for U.S. adults
AU - Campbell, Peter T.
AU - Newton, Christina C.
AU - Freedman, Neal D.
AU - Koshiol, Jill
AU - Alavanja, Michael C.
AU - Freeman, Laura E.Beane
AU - Buring, Julie E.
AU - Chan, Andrew T.
AU - Chong, Dawn Q.
AU - Datta, Mridul
AU - Gaudet, Mia M.
AU - Gaziano, J. Michael
AU - Giovannucci, Edward L.
AU - Graubard, Barry I.
AU - Hollenbeck, Albert R.
AU - King, Lindsey
AU - Lee, I. Min
AU - Linet, Martha S.
AU - Palmer, Julie R.
AU - Petrick, Jessica L.
AU - Poynter, Jenny N.
AU - Purdue, Mark P.
AU - Robien, Kim
AU - Rosenberg, Lynn
AU - Sahasrabuddhe, Vikrant V.
AU - Schairer, Catherine
AU - Sesso, Howard D.
AU - Sigurdson, Alice J.
AU - Stevens, Victoria L.
AU - Wactawski-Wende, Jean
AU - Zeleniuch-Jacquotte, Anne
AU - Renehan, Andrew G.
AU - McGlynn, Katherine A.
N1 - Publisher Copyright:
© 2016 American Association for Cancer Research.
PY - 2016/10/15
Y1 - 2016/10/15
N2 - Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus). Stratified analyses assessed whether the BMI-liver cancer associations differed by hepatitis sera-positivity in nested analyses for a subset of cases (n = 220) and controls (n = 547). After enrollment, 2,162 incident liver cancer diagnoses were identified. BMI, per 5 kg/m2, was associated with higher risks of liver cancer, more so for men (HR = 1.38; 95% CI, 1.30-1.46) than women (HR = 1.25; 95% CI, 1.17-1.35; Pinteraction = 0.02). WC, per 5 cm, was associated with higher risks of liver cancer, approximately equally by sex (overall, HR = 1.08; 95% CI, 1.04-1.13). Type II diabetes mellitus was associated with higher risk of liver cancer (HR = 2.61; 95% CI, 2.34-2.91). In stratified analyses, there was a null association between BMI and liver cancer risk for participants who were sera-positive for hepatitis. This study suggests that high BMI, high WC, and type II diabetes mellitus are associated with higher risks of liver cancer and that the association may differ by status of viral hepatitis infection.
AB - Incidence rates for liver cancer have increased 3-fold since the mid-1970s in the United States in parallel with increasing trends for obesity and type II diabetes mellitus. We conducted an analysis of baseline body mass index (BMI), waist circumference (WC), and type II diabetes mellitus with risk of liver cancer. The Liver Cancer Pooling Project maintains harmonized data from 1.57 million adults enrolled in 14 U.S.-based prospective studies. Cox regression estimated HRs and 95% confidence intervals (CI) adjusted for age, sex, study center, alcohol, smoking, race, and BMI (for WC and type II diabetes mellitus). Stratified analyses assessed whether the BMI-liver cancer associations differed by hepatitis sera-positivity in nested analyses for a subset of cases (n = 220) and controls (n = 547). After enrollment, 2,162 incident liver cancer diagnoses were identified. BMI, per 5 kg/m2, was associated with higher risks of liver cancer, more so for men (HR = 1.38; 95% CI, 1.30-1.46) than women (HR = 1.25; 95% CI, 1.17-1.35; Pinteraction = 0.02). WC, per 5 cm, was associated with higher risks of liver cancer, approximately equally by sex (overall, HR = 1.08; 95% CI, 1.04-1.13). Type II diabetes mellitus was associated with higher risk of liver cancer (HR = 2.61; 95% CI, 2.34-2.91). In stratified analyses, there was a null association between BMI and liver cancer risk for participants who were sera-positive for hepatitis. This study suggests that high BMI, high WC, and type II diabetes mellitus are associated with higher risks of liver cancer and that the association may differ by status of viral hepatitis infection.
UR - https://www.scopus.com/pages/publications/84991759835
U2 - 10.1158/0008-5472.CAN-16-0787
DO - 10.1158/0008-5472.CAN-16-0787
M3 - Article
C2 - 27742674
AN - SCOPUS:84991759835
SN - 0008-5472
VL - 76
SP - 6076
EP - 6083
JO - Cancer Research
JF - Cancer Research
IS - 20
ER -