BK virus associated with small cell carcinoma of bladder in a patient with renal transplant

Samantha J. Loria; Nabiya N. Siddiqui; Joy M. Gary; Julu Bhatnagar; Brigid C. Bollweg; Basem Ahmed; Charles S. Berenson

doi:10.1136/bcr-2021-244740

BK virus associated with small cell carcinoma of bladder in a patient with renal transplant

Samantha J. Loria
, Nabiya N. Siddiqui
, Joy M. Gary
, Julu Bhatnagar
, Brigid C. Bollweg
, Basem Ahmed
, Charles S. Berenson

Medicine

SUNY Buffalo
Centers for Disease Control and Prevention
Department of Veterans Affairs

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

A man in his 70s with a complex medical history, including cadaveric renal transplant, presented with recurrent urinary tract infections. Investigation revealed recurrent urinary pathogens, including Enterobacter cloacae and persistent BK viruria. Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. The tumour was treated with complete transurethral resection followed by carboplatin, etoposide and radiation. Laboratory analysis of biopsied samples showed immunostaining and molecular evidence of BK virus DNA in the cancer cells. Follow-up cystoscopies have shown no recurrence of the cancer.

Original language	English
Article number	e244740
Journal	BMJ Case Reports
Volume	15
Issue number	3
DOIs	https://doi.org/10.1136/bcr-2021-244740
State	Published - Mar 2022

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title = "BK virus associated with small cell carcinoma of bladder in a patient with renal transplant",

abstract = "A man in his 70s with a complex medical history, including cadaveric renal transplant, presented with recurrent urinary tract infections. Investigation revealed recurrent urinary pathogens, including Enterobacter cloacae and persistent BK viruria. Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. The tumour was treated with complete transurethral resection followed by carboplatin, etoposide and radiation. Laboratory analysis of biopsied samples showed immunostaining and molecular evidence of BK virus DNA in the cancer cells. Follow-up cystoscopies have shown no recurrence of the cancer.",

author = "Loria, \{Samantha J.\} and Siddiqui, \{Nabiya N.\} and Gary, \{Joy M.\} and Julu Bhatnagar and Bollweg, \{Brigid C.\} and Basem Ahmed and Berenson, \{Charles S.\}",

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year = "2022",

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doi = "10.1136/bcr-2021-244740",

language = "English",

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TY - JOUR

T1 - BK virus associated with small cell carcinoma of bladder in a patient with renal transplant

AU - Loria, Samantha J.

AU - Siddiqui, Nabiya N.

AU - Gary, Joy M.

AU - Bhatnagar, Julu

AU - Bollweg, Brigid C.

AU - Ahmed, Basem

AU - Berenson, Charles S.

PY - 2022/3

Y1 - 2022/3

N2 - A man in his 70s with a complex medical history, including cadaveric renal transplant, presented with recurrent urinary tract infections. Investigation revealed recurrent urinary pathogens, including Enterobacter cloacae and persistent BK viruria. Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. The tumour was treated with complete transurethral resection followed by carboplatin, etoposide and radiation. Laboratory analysis of biopsied samples showed immunostaining and molecular evidence of BK virus DNA in the cancer cells. Follow-up cystoscopies have shown no recurrence of the cancer.

AB - A man in his 70s with a complex medical history, including cadaveric renal transplant, presented with recurrent urinary tract infections. Investigation revealed recurrent urinary pathogens, including Enterobacter cloacae and persistent BK viruria. Cystoscopy revealed a pedunculated mass in the right posterior-lateral wall, inferior to the transplant urethral orifice, and biopsy of this mass showed invasive small cell carcinoma with a prominent adenocarcinoma component. The tumour was treated with complete transurethral resection followed by carboplatin, etoposide and radiation. Laboratory analysis of biopsied samples showed immunostaining and molecular evidence of BK virus DNA in the cancer cells. Follow-up cystoscopies have shown no recurrence of the cancer.

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DO - 10.1136/bcr-2021-244740

M3 - Article

C2 - 35351771

AN - SCOPUS:85127245034

SN - 1757-790X

VL - 15

JO - BMJ Case Reports

JF - BMJ Case Reports

IS - 3

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ER -

BK virus associated with small cell carcinoma of bladder in a patient with renal transplant

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