Biology of Castration-Recurrent Prostate Cancer

Faris Azzouni; James Mohler

doi:10.1016/j.ucl.2012.07.002

Biology of Castration-Recurrent Prostate Cancer

Faris Azzouni
, James Mohler

Department of Urology

Roswell Park Cancer Institute

Research output: Contribution to journal › Review article › peer-review

26 Scopus citations

Abstract

Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.

Original language	English
Pages (from-to)	435-452
Number of pages	18
Journal	Urologic Clinics of North America
Volume	39
Issue number	4
DOIs	https://doi.org/10.1016/j.ucl.2012.07.002
State	Published - Nov 2012

Keywords

Biology
Castration recurrent
Castration resistant
Mechanism
Prostate cancer

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10.1016/j.ucl.2012.07.002

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@article{3e050fc35311406587b53b77f1e3c162,

title = "Biology of Castration-Recurrent Prostate Cancer",

abstract = "Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.",

keywords = "Biology, Castration recurrent, Castration resistant, Mechanism, Prostate cancer",

author = "Faris Azzouni and James Mohler",

year = "2012",

month = nov,

doi = "10.1016/j.ucl.2012.07.002",

language = "English",

volume = "39",

pages = "435--452",

journal = "Urologic Clinics of North America",

issn = "0094-0143",

publisher = "W.B. Saunders",

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}

TY - JOUR

T1 - Biology of Castration-Recurrent Prostate Cancer

AU - Azzouni, Faris

AU - Mohler, James

PY - 2012/11

Y1 - 2012/11

N2 - Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.

AB - Although androgen-deprivation therapy is the standard therapy for advanced and metastatic prostate cancer, this treatment is only palliative. Prostate cancer recurs then grows despite low circulating testicular androgens, using several mechanisms that remain dependent on androgen-receptor signaling in most cases. This article reviews the diversity of mechanisms used for growth by castration-recurrent prostate cancer.

KW - Biology

KW - Castration recurrent

KW - Castration resistant

KW - Mechanism

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/84867663093

U2 - 10.1016/j.ucl.2012.07.002

DO - 10.1016/j.ucl.2012.07.002

M3 - Review article

C2 - 23084522

AN - SCOPUS:84867663093

SN - 0094-0143

VL - 39

SP - 435

EP - 452

JO - Urologic Clinics of North America

JF - Urologic Clinics of North America

IS - 4

ER -

Biology of Castration-Recurrent Prostate Cancer

Abstract

Keywords

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