Binding of EuIII to 1,2-hydroxypyridinone-modified peptide nucleic acids

Arnie R. De Leon; Abiola O. Olatunde; Janet R. Morrow; Catalina Achim

doi:10.1021/ic301790v

Binding of Eu^III to 1,2-hydroxypyridinone-modified peptide nucleic acids

Arnie R. De Leon
, Abiola O. Olatunde
, Janet R. Morrow
, Catalina Achim

Chemistry

Carnegie Mellon University
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for Eu^III as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu ^III excitation spectra and luminescence lifetime data are consistent with Eu^III bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution.

Original language	English
Pages (from-to)	12597-12599
Number of pages	3
Journal	Inorganic Chemistry
Volume	51
Issue number	23
DOIs	https://doi.org/10.1021/ic301790v
State	Published - Dec 3 2012

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title = "Binding of EuIII to 1,2-hydroxypyridinone-modified peptide nucleic acids",

abstract = "Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for EuIII as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu III excitation spectra and luminescence lifetime data are consistent with EuIII bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution.",

author = "\{De Leon\}, \{Arnie R.\} and Olatunde, \{Abiola O.\} and Morrow, \{Janet R.\} and Catalina Achim",

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T1 - Binding of EuIII to 1,2-hydroxypyridinone-modified peptide nucleic acids

AU - De Leon, Arnie R.

AU - Olatunde, Abiola O.

AU - Morrow, Janet R.

AU - Achim, Catalina

PY - 2012/12/3

Y1 - 2012/12/3

N2 - Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for EuIII as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu III excitation spectra and luminescence lifetime data are consistent with EuIII bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution.

AB - Substitution of a nucleobase pair with a pair of 1,2-hydroxypyridinone (1,2-HOPO) ligands in the center of a 10-base-pair peptide nucleic acid (PNA) duplex provides a strong binding site for EuIII as evidenced by UV thermal melting curves, UV titrations, and luminescence spectroscopy. Eu III excitation spectra and luminescence lifetime data are consistent with EuIII bound to both 1,2 HOPO ligands in a PNA-HOPO duplex as the major species present in solution.

UR - https://www.scopus.com/pages/publications/84870479597

U2 - 10.1021/ic301790v

DO - 10.1021/ic301790v

M3 - Article

C2 - 23148561

AN - SCOPUS:84870479597

SN - 0020-1669

VL - 51

SP - 12597

EP - 12599

JO - Inorganic Chemistry

JF - Inorganic Chemistry

IS - 23

ER -

Binding of Eu^III to 1,2-hydroxypyridinone-modified peptide nucleic acids

Abstract

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