Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

Taghreed Almahmeed; Jay O. Boyle; Erik G. Cohen; John F. Carew; Baoheng Du; Nasser K. Altorki; Levy Kopelovich; Jia Long Fang; Philip Lazarus; Kotha Subbaramaiah; Andrew J. Dannenberg

doi:10.1093/carcin/bgh078

Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

Taghreed Almahmeed
, Jay O. Boyle
, Erik G. Cohen
, John F. Carew
, Baoheng Du
, Nasser K. Altorki
, Levy Kopelovich
, Jia Long Fang
, Philip Lazarus
, Kotha Subbaramaiah
, Andrew J. Dannenberg

Pharmaceutical Sciences

Memorial Sloan-Kettering Cancer Center
Cornell University
National Institutes of Health
Moffitt Cancer Center
Strang Cancer Prevention Center

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

Original language	English
Pages (from-to)	793-799
Number of pages	7
Journal	Carcinogenesis
Volume	25
Issue number	5
DOIs	https://doi.org/10.1093/carcin/bgh078
State	Published - May 2004

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Almahmeed, T., Boyle, J. O., Cohen, E. G., Carew, J. F., Du, B., Altorki, N. K., Kopelovich, L., Fang, J. L., Lazarus, P., Subbaramaiah, K., & Dannenberg, A. J. (2004). Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract. Carcinogenesis, 25(5), 793-799. https://doi.org/10.1093/carcin/bgh078

@article{25c90f7709314651b3c7299da802fa80,

title = "Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract",

abstract = "In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.",

author = "Taghreed Almahmeed and Boyle, \{Jay O.\} and Cohen, \{Erik G.\} and Carew, \{John F.\} and Baoheng Du and Altorki, \{Nasser K.\} and Levy Kopelovich and Fang, \{Jia Long\} and Philip Lazarus and Kotha Subbaramaiah and Dannenberg, \{Andrew J.\}",

year = "2004",

month = may,

doi = "10.1093/carcin/bgh078",

language = "English",

volume = "25",

pages = "793--799",

journal = "Carcinogenesis",

issn = "0143-3334",

publisher = "Oxford University Press",

number = "5",

}

Almahmeed, T, Boyle, JO, Cohen, EG, Carew, JF, Du, B, Altorki, NK, Kopelovich, L, Fang, JL, Lazarus, P, Subbaramaiah, K & Dannenberg, AJ 2004, 'Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract', Carcinogenesis, vol. 25, no. 5, pp. 793-799. https://doi.org/10.1093/carcin/bgh078

TY - JOUR

T1 - Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

AU - Almahmeed, Taghreed

AU - Boyle, Jay O.

AU - Cohen, Erik G.

AU - Carew, John F.

AU - Du, Baoheng

AU - Altorki, Nasser K.

AU - Kopelovich, Levy

AU - Fang, Jia Long

AU - Lazarus, Philip

AU - Subbaramaiah, Kotha

AU - Dannenberg, Andrew J.

PY - 2004/5

Y1 - 2004/5

N2 - In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

AB - In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10.

UR - https://www.scopus.com/pages/publications/2442625584

U2 - 10.1093/carcin/bgh078

DO - 10.1093/carcin/bgh078

M3 - Article

C2 - 14729581

AN - SCOPUS:2442625584

SN - 0143-3334

VL - 25

SP - 793

EP - 799

JO - Carcinogenesis

JF - Carcinogenesis

IS - 5

ER -

Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract

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