Balance optimization subset selection (BOSS): An alternative approach for causal inference with observational data

Scientists in all disciplines attempt to identify and document causal relationships. Those not fortunate enough to be able to design and implement randomized control trials must resort to observational studies. To make causal inferences outside the experimental realm, researchers attempt to control for bias sources by postprocessing observational data. Finding the subset of data most conducive to unbiased or least biased treatment effect estimation is a challenging, complex problem. However, the rise in computational power and algorithmic sophistication leads to an operations research solution that circumvents many of the challenges presented by methods employed over the past 30 years.