Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations

Raymond Cha; William J. Brown; Michael J. Rybak

doi:10.1128/AAC.47.12.3960-3963.2003

Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations

Raymond Cha
, William J. Brown
, Michael J. Rybak

Pharmacy

Wayne State University

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.

Original language	English
Pages (from-to)	3960-3963
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	47
Issue number	12
DOIs	https://doi.org/10.1128/AAC.47.12.3960-3963.2003
State	Published - Dec 2003

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title = "Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations",

abstract = "In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.",

author = "Raymond Cha and Brown, \{William J.\} and Rybak, \{Michael J.\}",

year = "2003",

month = dec,

doi = "10.1128/AAC.47.12.3960-3963.2003",

language = "English",

volume = "47",

pages = "3960--3963",

journal = "Antimicrobial Agents and Chemotherapy",

issn = "0066-4804",

publisher = "American Society for Microbiology",

number = "12",

}

Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations. / Cha, Raymond; Brown, William J.; Rybak, Michael J.
In: Antimicrobial Agents and Chemotherapy, Vol. 47, No. 12, 12.2003, p. 3960-3963.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations

AU - Cha, Raymond

AU - Brown, William J.

AU - Rybak, Michael J.

PY - 2003/12

Y1 - 2003/12

N2 - In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.

AB - In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.

UR - https://www.scopus.com/pages/publications/0344011995

U2 - 10.1128/AAC.47.12.3960-3963.2003

DO - 10.1128/AAC.47.12.3960-3963.2003

M3 - Article

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AN - SCOPUS:0344011995

SN - 0066-4804

VL - 47

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JO - Antimicrobial Agents and Chemotherapy

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IS - 12

ER -

Bactericidal Activities of Daptomycin, Quinupristin-Dalfopristin, and Linezolid against Vancomycin-Resistant Staphylococcus aureus in an In Vitro Pharmacodynamic Model with Simulated Endocardial Vegetations

Abstract

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