Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana

Pennante Bruce-Vanderpuije; David Megson; Karl Jobst; Gareth Rhys Jones; Eric Reiner; Court D. Sandau; Edith Clarke; Sam Adu-Kumi; Joseph A. Gardella

doi:10.1016/j.scitotenv.2019.04.060

Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana

Pennante Bruce-Vanderpuije
, David Megson
, Karl Jobst
, Gareth Rhys Jones
, Eric Reiner
, Court D. Sandau
, Edith Clarke
, Sam Adu-Kumi
, Joseph A. Gardella

Chemistry

SUNY Buffalo
The Council for Scientific and Industrial Research
Manchester Metropolitan University
Chemistry Matters Inc.
Government of Ontario
Waters Corporation,United Kingdom
Mount Royal University
Ministry of Health, Ghana
Environmental Protection Agency

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Human exposure data on dioxins and dioxin-like compounds (DLCs) in Ghana are limited. Based on health risks associated with dioxins and DLCs, the impact of maternal body burdens on foetal exposure is significant. This is the first study that assesses polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs and PXDD/Fs), and dioxin-like polychlorinated biphenyls (dlPCBs) in sera of primiparous Ghanaians. Our sample selection includes 34 participants from two municipalities (Accra and Tema), and explores contributions from environmental and dietary exposures using questionnaire data. Sample preparation involved C ₁₈ solid phase extraction, purification with acidified silica and lipid removal cartridges, and detection with gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. The calculated average toxic equivalent concentration was 5.3 pg TEQ/g lw, with contributions from dlPCBs (1.25 pg TEQ/g lw), PCDD/Fs (3.10 pg TEQ/g lw), PBDD/Fs (0.49 pg TEQ/g lw) and PXDD/Fs (0.50 pg TEQ/g lw). The calculated total TEQ concentration was lower than background TEQ concentrations reported in sera of pregnant women globally. Positive correlations were obtained for total dioxins and DLC concentrations with age and Body Mass Index (BMI). Dietary intake of seafood and dairy products had a strong influence on PCDD/F and dlPCB concentrations. Statistically significant differences were observed for dioxins and DLCs in participants from Accra (in close proximity to Agbogbloshie e-waste site) and Tema. Given the significant TEQ contribution of PBDD/Fs and PXDD/Fs (~20%), it is essential to explore these classes of dioxins and DLCs in future biomonitoring studies as they may pose health risks, and add extra diagnostic information in source exposure investigations.

Original language	English
Pages (from-to)	631-642
Number of pages	12
Journal	Science of the Total Environment
Volume	673
DOIs	https://doi.org/10.1016/j.scitotenv.2019.04.060
State	Published - Jul 10 2019

Keywords

Background concentrations
Dioxin-like compounds
Dioxins
Ghana
Pregnant women
Serum

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Bruce-Vanderpuije, P., Megson, D., Jobst, K., Jones, G. R., Reiner, E., Sandau, C. D., Clarke, E., Adu-Kumi, S., & Gardella, J. A. (2019). Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana. Science of the Total Environment, 673, 631-642. https://doi.org/10.1016/j.scitotenv.2019.04.060

@article{63e5da7df60644bbaa03ddc7d0214605,

title = "Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs \& PXDD/Fs) in sera of pregnant women in Accra, Ghana",

abstract = " Human exposure data on dioxins and dioxin-like compounds (DLCs) in Ghana are limited. Based on health risks associated with dioxins and DLCs, the impact of maternal body burdens on foetal exposure is significant. This is the first study that assesses polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs and PXDD/Fs), and dioxin-like polychlorinated biphenyls (dlPCBs) in sera of primiparous Ghanaians. Our sample selection includes 34 participants from two municipalities (Accra and Tema), and explores contributions from environmental and dietary exposures using questionnaire data. Sample preparation involved C 18 solid phase extraction, purification with acidified silica and lipid removal cartridges, and detection with gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. The calculated average toxic equivalent concentration was 5.3 pg TEQ/g lw, with contributions from dlPCBs (1.25 pg TEQ/g lw), PCDD/Fs (3.10 pg TEQ/g lw), PBDD/Fs (0.49 pg TEQ/g lw) and PXDD/Fs (0.50 pg TEQ/g lw). The calculated total TEQ concentration was lower than background TEQ concentrations reported in sera of pregnant women globally. Positive correlations were obtained for total dioxins and DLC concentrations with age and Body Mass Index (BMI). Dietary intake of seafood and dairy products had a strong influence on PCDD/F and dlPCB concentrations. Statistically significant differences were observed for dioxins and DLCs in participants from Accra (in close proximity to Agbogbloshie e-waste site) and Tema. Given the significant TEQ contribution of PBDD/Fs and PXDD/Fs (\textasciitilde{}20\%), it is essential to explore these classes of dioxins and DLCs in future biomonitoring studies as they may pose health risks, and add extra diagnostic information in source exposure investigations.",

keywords = "Background concentrations, Dioxin-like compounds, Dioxins, Ghana, Pregnant women, Serum",

author = "Pennante Bruce-Vanderpuije and David Megson and Karl Jobst and Jones, \{Gareth Rhys\} and Eric Reiner and Sandau, \{Court D.\} and Edith Clarke and Sam Adu-Kumi and Gardella, \{Joseph A.\}",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = jul,

day = "10",

doi = "10.1016/j.scitotenv.2019.04.060",

language = "English",

volume = "673",

pages = "631--642",

journal = "Science of the Total Environment",

issn = "0048-9697",

publisher = "Elsevier B.V.",

}

Bruce-Vanderpuije, P, Megson, D, Jobst, K, Jones, GR, Reiner, E, Sandau, CD, Clarke, E, Adu-Kumi, S & Gardella, JA 2019, 'Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana', Science of the Total Environment, vol. 673, pp. 631-642. https://doi.org/10.1016/j.scitotenv.2019.04.060

Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana. / Bruce-Vanderpuije, Pennante; Megson, David; Jobst, Karl et al.
In: Science of the Total Environment, Vol. 673, 10.07.2019, p. 631-642.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana

AU - Bruce-Vanderpuije, Pennante

AU - Megson, David

AU - Jobst, Karl

AU - Jones, Gareth Rhys

AU - Reiner, Eric

AU - Sandau, Court D.

AU - Clarke, Edith

AU - Adu-Kumi, Sam

AU - Gardella, Joseph A.

PY - 2019/7/10

Y1 - 2019/7/10

N2 - Human exposure data on dioxins and dioxin-like compounds (DLCs) in Ghana are limited. Based on health risks associated with dioxins and DLCs, the impact of maternal body burdens on foetal exposure is significant. This is the first study that assesses polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs and PXDD/Fs), and dioxin-like polychlorinated biphenyls (dlPCBs) in sera of primiparous Ghanaians. Our sample selection includes 34 participants from two municipalities (Accra and Tema), and explores contributions from environmental and dietary exposures using questionnaire data. Sample preparation involved C 18 solid phase extraction, purification with acidified silica and lipid removal cartridges, and detection with gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. The calculated average toxic equivalent concentration was 5.3 pg TEQ/g lw, with contributions from dlPCBs (1.25 pg TEQ/g lw), PCDD/Fs (3.10 pg TEQ/g lw), PBDD/Fs (0.49 pg TEQ/g lw) and PXDD/Fs (0.50 pg TEQ/g lw). The calculated total TEQ concentration was lower than background TEQ concentrations reported in sera of pregnant women globally. Positive correlations were obtained for total dioxins and DLC concentrations with age and Body Mass Index (BMI). Dietary intake of seafood and dairy products had a strong influence on PCDD/F and dlPCB concentrations. Statistically significant differences were observed for dioxins and DLCs in participants from Accra (in close proximity to Agbogbloshie e-waste site) and Tema. Given the significant TEQ contribution of PBDD/Fs and PXDD/Fs (~20%), it is essential to explore these classes of dioxins and DLCs in future biomonitoring studies as they may pose health risks, and add extra diagnostic information in source exposure investigations.

AB - Human exposure data on dioxins and dioxin-like compounds (DLCs) in Ghana are limited. Based on health risks associated with dioxins and DLCs, the impact of maternal body burdens on foetal exposure is significant. This is the first study that assesses polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs and PXDD/Fs), and dioxin-like polychlorinated biphenyls (dlPCBs) in sera of primiparous Ghanaians. Our sample selection includes 34 participants from two municipalities (Accra and Tema), and explores contributions from environmental and dietary exposures using questionnaire data. Sample preparation involved C 18 solid phase extraction, purification with acidified silica and lipid removal cartridges, and detection with gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. The calculated average toxic equivalent concentration was 5.3 pg TEQ/g lw, with contributions from dlPCBs (1.25 pg TEQ/g lw), PCDD/Fs (3.10 pg TEQ/g lw), PBDD/Fs (0.49 pg TEQ/g lw) and PXDD/Fs (0.50 pg TEQ/g lw). The calculated total TEQ concentration was lower than background TEQ concentrations reported in sera of pregnant women globally. Positive correlations were obtained for total dioxins and DLC concentrations with age and Body Mass Index (BMI). Dietary intake of seafood and dairy products had a strong influence on PCDD/F and dlPCB concentrations. Statistically significant differences were observed for dioxins and DLCs in participants from Accra (in close proximity to Agbogbloshie e-waste site) and Tema. Given the significant TEQ contribution of PBDD/Fs and PXDD/Fs (~20%), it is essential to explore these classes of dioxins and DLCs in future biomonitoring studies as they may pose health risks, and add extra diagnostic information in source exposure investigations.

KW - Background concentrations

KW - Dioxin-like compounds

KW - Dioxins

KW - Ghana

KW - Pregnant women

KW - Serum

UR - https://www.scopus.com/pages/publications/85064190082

U2 - 10.1016/j.scitotenv.2019.04.060

DO - 10.1016/j.scitotenv.2019.04.060

M3 - Article

C2 - 30999104

AN - SCOPUS:85064190082

SN - 0048-9697

VL - 673

SP - 631

EP - 642

JO - Science of the Total Environment

JF - Science of the Total Environment

ER -

Bruce-Vanderpuije P, Megson D, Jobst K, Jones GR, Reiner E, Sandau CD et al. Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana. Science of the Total Environment. 2019 Jul 10;673:631-642. doi: 10.1016/j.scitotenv.2019.04.060

Background levels of dioxin-like polychlorinated biphenyls (dlPCBs), polychlorinated, polybrominated and mixed halogenated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs, PBDD/Fs & PXDD/Fs) in sera of pregnant women in Accra, Ghana

Abstract

Keywords

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