B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

Chengyang Liu; Hooman Noorchashm; Jennifer A. Sutter; Mina Naji; Eline Luning Prak; Jean Boyer; Taryn Green; Michael R. Rickels; John E. Tomaszewski; Brigitte Koeberlein; Zhonglin Wang; Michelle E. Paessler; Ergun Velidedeoglu; Susan Y. Rostami; Ming Yu; Clyde F. Barker; Ali Naji

doi:10.1038/nm1673

B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

Chengyang Liu
, Hooman Noorchashm
, Jennifer A. Sutter
, Mina Naji
, Eline Luning Prak
, Jean Boyer
, Taryn Green
, Michael R. Rickels
, John E. Tomaszewski
, Brigitte Koeberlein
, Zhonglin Wang
, Michelle E. Paessler
, Ergun Velidedeoglu
, Susan Y. Rostami
, Ming Yu
, Clyde F. Barker
, Ali Naji

Department of Pathology and Anatomical Sciences

University of Pennsylvania
Children's Hospital of Philadelphia

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.

Original language	English
Pages (from-to)	1295-1298
Number of pages	4
Journal	Nature Medicine
Volume	13
Issue number	11
DOIs	https://doi.org/10.1038/nm1673
State	Published - Nov 2007

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Liu, C., Noorchashm, H., Sutter, J. A., Naji, M., Prak, E. L., Boyer, J., Green, T., Rickels, M. R., Tomaszewski, J. E., Koeberlein, B., Wang, Z., Paessler, M. E., Velidedeoglu, E., Rostami, S. Y., Yu, M., Barker, C. F., & Naji, A. (2007). B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates. Nature Medicine, 13(11), 1295-1298. https://doi.org/10.1038/nm1673

@article{c8e3872a81194cd79edd65dba8ff5556,

title = "B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates",

abstract = "We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.",

author = "Chengyang Liu and Hooman Noorchashm and Sutter, \{Jennifer A.\} and Mina Naji and Prak, \{Eline Luning\} and Jean Boyer and Taryn Green and Rickels, \{Michael R.\} and Tomaszewski, \{John E.\} and Brigitte Koeberlein and Zhonglin Wang and Paessler, \{Michelle E.\} and Ergun Velidedeoglu and Rostami, \{Susan Y.\} and Ming Yu and Barker, \{Clyde F.\} and Ali Naji",

year = "2007",

month = nov,

doi = "10.1038/nm1673",

language = "English",

volume = "13",

pages = "1295--1298",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Research",

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}

Liu, C, Noorchashm, H, Sutter, JA, Naji, M, Prak, EL, Boyer, J, Green, T, Rickels, MR, Tomaszewski, JE, Koeberlein, B, Wang, Z, Paessler, ME, Velidedeoglu, E, Rostami, SY, Yu, M, Barker, CF & Naji, A 2007, 'B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates', Nature Medicine, vol. 13, no. 11, pp. 1295-1298. https://doi.org/10.1038/nm1673

TY - JOUR

T1 - B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

AU - Liu, Chengyang

AU - Noorchashm, Hooman

AU - Sutter, Jennifer A.

AU - Naji, Mina

AU - Prak, Eline Luning

AU - Boyer, Jean

AU - Green, Taryn

AU - Rickels, Michael R.

AU - Tomaszewski, John E.

AU - Koeberlein, Brigitte

AU - Wang, Zhonglin

AU - Paessler, Michelle E.

AU - Velidedeoglu, Ergun

AU - Rostami, Susan Y.

AU - Yu, Ming

AU - Barker, Clyde F.

AU - Naji, Ali

PY - 2007/11

Y1 - 2007/11

N2 - We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.

AB - We found that an induction immunotherapy regimen consisting of rabbit anti-thymocyte globulin (Thymoglobulin) and the monoclonal antibody to CD20 rituximab (Rituxan) promoted long-term islet allograft survival in cynomolgus macaques maintained on rapamycin monotherapy. B lymphocyte reconstitution after rituximab-mediated depletion was characterized by a preponderance of immature and transitional cells, whose persistence was associated with long-term islet allograft survival. Development of donor-specific alloantibodies was abrogated only in the setting of continued rapamycin monotherapy.

UR - https://www.scopus.com/pages/publications/35948935946

U2 - 10.1038/nm1673

DO - 10.1038/nm1673

M3 - Article

C2 - 17965721

AN - SCOPUS:35948935946

SN - 1078-8956

VL - 13

SP - 1295

EP - 1298

JO - Nature Medicine

JF - Nature Medicine

IS - 11

ER -

B lymphocyte-directed immunotherapy promotes long-term islet allograft survival in nonhuman primates

Abstract

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