Azirine ligation: Fast and selective protein conjugation via photoinduced azirine-alkene cycloaddition

Reyna K.V. Lim; Qing Lin

doi:10.1039/c0cc02863k

Azirine ligation: Fast and selective protein conjugation via photoinduced azirine-alkene cycloaddition

Reyna K.V. Lim
, Qing Lin

Chemistry

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (∼2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.

Original language	English
Pages (from-to)	7993-7995
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	42
DOIs	https://doi.org/10.1039/c0cc02863k
State	Published - Nov 14 2010

Access to Document

10.1039/c0cc02863k

Cite this

@article{55281af4b1ea45c38c68839b5baf67d0,

title = "Azirine ligation: Fast and selective protein conjugation via photoinduced azirine-alkene cycloaddition",

abstract = "We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (∼2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.",

author = "Lim, \{Reyna K.V.\} and Qing Lin",

year = "2010",

month = nov,

day = "14",

doi = "10.1039/c0cc02863k",

language = "English",

volume = "46",

pages = "7993--7995",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "42",

}

TY - JOUR

T1 - Azirine ligation

T2 - Fast and selective protein conjugation via photoinduced azirine-alkene cycloaddition

AU - Lim, Reyna K.V.

AU - Lin, Qing

PY - 2010/11/14

Y1 - 2010/11/14

N2 - We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (∼2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.

AB - We report a new bioorthogonal ligation reaction between p-nitrodiphenylazirine and dimethyl fumarate. This photoinduced azirine-alkene cycloaddition provides a rapid (∼2 min) and highly selective route to protein conjugation at neutral pH and room temperature in biological medium.

UR - https://www.scopus.com/pages/publications/77958470555

U2 - 10.1039/c0cc02863k

DO - 10.1039/c0cc02863k

M3 - Article

C2 - 20865197

AN - SCOPUS:77958470555

SN - 1359-7345

VL - 46

SP - 7993

EP - 7995

JO - Chemical Communications

JF - Chemical Communications

IS - 42

ER -

Azirine ligation: Fast and selective protein conjugation via photoinduced azirine-alkene cycloaddition

Abstract

Access to Document

Other files and links

Fingerprint

Cite this