Autoradiographic localization of 2-[125I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice

Judith A. Siuciak; Jun Ming Fang; Margarita L. Dubocovich

doi:10.1016/0014-2999(90)90328-4

Autoradiographic localization of 2-[¹²⁵I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice

Judith A. Siuciak
, Jun Ming Fang
, Margarita L. Dubocovich

Pharmacology and Toxicology

Northwestern University

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

The present study uses in vitro autoradiography to localize 2-[¹²⁵I]iodemelatonin binding sites in the brain of two strains of mice, the C3H/HeN and the C57BL/6J, which have been shown to exhibit differences in pineal melatonin content. We found a differential pattern of distribution of 2-[¹²⁵I]iodomelatonin binding sites between the two strains with the suprachiasmatic nucleus, paraventricular nucleus of the thalamus, regions labelled in both strains. These studies should help to interpret behavioral changes due to activation of melatonin receptors in these strains of mice.

Original language	English
Pages (from-to)	387-390
Number of pages	4
Journal	European Journal of Pharmacology
Volume	180
Issue number	2-3
DOIs	https://doi.org/10.1016/0014-2999(90)90328-4
State	Published - May 16 1990

Keywords

2-[I]Iodomelatonin
C57BL/6J mice
CH/HeN
Melatonin
Receptor autoradiography

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10.1016/0014-2999(90)90328-4

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title = "Autoradiographic localization of 2-[125I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice",

abstract = "The present study uses in vitro autoradiography to localize 2-[125I]iodemelatonin binding sites in the brain of two strains of mice, the C3H/HeN and the C57BL/6J, which have been shown to exhibit differences in pineal melatonin content. We found a differential pattern of distribution of 2-[125I]iodomelatonin binding sites between the two strains with the suprachiasmatic nucleus, paraventricular nucleus of the thalamus, regions labelled in both strains. These studies should help to interpret behavioral changes due to activation of melatonin receptors in these strains of mice.",

keywords = "2-[I]Iodomelatonin, C57BL/6J mice, CH/HeN, Melatonin, Receptor autoradiography",

author = "Siuciak, \{Judith A.\} and Fang, \{Jun Ming\} and Dubocovich, \{Margarita L.\}",

year = "1990",

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doi = "10.1016/0014-2999(90)90328-4",

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T1 - Autoradiographic localization of 2-[125I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice

AU - Siuciak, Judith A.

AU - Fang, Jun Ming

AU - Dubocovich, Margarita L.

PY - 1990/5/16

Y1 - 1990/5/16

N2 - The present study uses in vitro autoradiography to localize 2-[125I]iodemelatonin binding sites in the brain of two strains of mice, the C3H/HeN and the C57BL/6J, which have been shown to exhibit differences in pineal melatonin content. We found a differential pattern of distribution of 2-[125I]iodomelatonin binding sites between the two strains with the suprachiasmatic nucleus, paraventricular nucleus of the thalamus, regions labelled in both strains. These studies should help to interpret behavioral changes due to activation of melatonin receptors in these strains of mice.

AB - The present study uses in vitro autoradiography to localize 2-[125I]iodemelatonin binding sites in the brain of two strains of mice, the C3H/HeN and the C57BL/6J, which have been shown to exhibit differences in pineal melatonin content. We found a differential pattern of distribution of 2-[125I]iodomelatonin binding sites between the two strains with the suprachiasmatic nucleus, paraventricular nucleus of the thalamus, regions labelled in both strains. These studies should help to interpret behavioral changes due to activation of melatonin receptors in these strains of mice.

KW - 2-[I]Iodomelatonin

KW - C57BL/6J mice

KW - CH/HeN

KW - Melatonin

KW - Receptor autoradiography

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SN - 0014-2999

VL - 180

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EP - 390

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2-3

ER -

Autoradiographic localization of 2-[¹²⁵I]iodomelatonin binding sites in the brains of C3H/HeN and C57BL/6J strains of mice

Abstract

Keywords

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