@inproceedings{c3998c92e99f4ab18a57108d1689b479,
title = "Automated matching of genomic structures in microscopic images of living cells using an information theoretic approach",
abstract = "Advances in microscopic imaging technology have revolutionized biology in recent years by enabling the study of dynamic processes inside living cells. Time-lapse microscopy produces large numbers of sequential images of living cells taken over time. In this paper we describe the novel approaches we have developed to automate and introduce high accuracy to the process of identifying genomic structures in living cells and matching them between consecutive time-points. We derive control points from landmarks within the structures and use the Kulback-Leibler divergence as an information-theoretic approach to correctly resolve potential close matches within the iterative closest point (ICP) algorithm. We also describe the steps needed to extend our techniques to analyze three dimensional voxel images. The approaches we describe are widely applicable in the analysis of time-lapse microscopy data.",
author = "S. Bhattacharya and R. Acharya and A. Pliss and Malyavantham, \{K. S.\} and R. Berezney",
year = "2005",
doi = "10.1109/iembs.2005.1615969",
language = "English",
isbn = "0780387406",
series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "6425--6428",
booktitle = "Proceedings of the 2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005",
address = "United States",
note = "2005 27th Annual International Conference of the Engineering in Medicine and Biology Society, IEEE-EMBS 2005 ; Conference date: 01-09-2005 Through 04-09-2005",
}