Attenuation correction for the NIH ATLAS small animal PET scanner

Rutao Yao; Jürgen Seidel; Jeih San Liow; Michael V. Green

Attenuation correction for the NIH ATLAS small animal PET scanner

Rutao Yao
, Jürgen Seidel
, Jeih San Liow
, Michael V. Green

Radiology

National Institutes of Health

Research output: Contribution to journal › Conference article › peer-review

Abstract

We evaluated two methods of attenuation correction for the NIH ATLAS small animal PET scanner: 1) a CT-based method that derives 511 keV attenuation coefficients (μ) by extrapolation from spatially registered CT images; and 2) an analytic method based on the body outline of emission images and an empirical μ. A specially fabricated attenuation calibration phantom with cylindrical inserts that mimic different body tissues was used to derive the relationship to convert CT values to (I for PET. The methods were applied to three test data sets: 1) a uniform cylinder phantom, 2) the attenuation calibration phantom, and 3) a mouse injected with [ ¹⁸F] FDG. The CT-based attenuation correction factors were larger in non-uniform regions of the imaging subject, e.g. mouse head, than the analytic method. The two methods had similar correction factors for regions with uniform density and detectable emission source distributions.

Original language	English
Article number	M7-27
Pages (from-to)	2283-2287
Number of pages	5
Journal	IEEE Nuclear Science Symposium Conference Record
Volume	4
State	Published - 2003
Event	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States Duration: Oct 19 2003 → Oct 25 2003

Cite this

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title = "Attenuation correction for the NIH ATLAS small animal PET scanner",

abstract = "We evaluated two methods of attenuation correction for the NIH ATLAS small animal PET scanner: 1) a CT-based method that derives 511 keV attenuation coefficients (μ) by extrapolation from spatially registered CT images; and 2) an analytic method based on the body outline of emission images and an empirical μ. A specially fabricated attenuation calibration phantom with cylindrical inserts that mimic different body tissues was used to derive the relationship to convert CT values to (I for PET. The methods were applied to three test data sets: 1) a uniform cylinder phantom, 2) the attenuation calibration phantom, and 3) a mouse injected with [ 18F] FDG. The CT-based attenuation correction factors were larger in non-uniform regions of the imaging subject, e.g. mouse head, than the analytic method. The two methods had similar correction factors for regions with uniform density and detectable emission source distributions.",

author = "Rutao Yao and J{\"u}rgen Seidel and Liow, \{Jeih San\} and Green, \{Michael V.\}",

year = "2003",

language = "English",

volume = "4",

pages = "2283--2287",

journal = "IEEE Nuclear Science Symposium Conference Record",

issn = "1095-7863",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference ; Conference date: 19-10-2003 Through 25-10-2003",

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TY - JOUR

T1 - Attenuation correction for the NIH ATLAS small animal PET scanner

AU - Yao, Rutao

AU - Seidel, Jürgen

AU - Liow, Jeih San

AU - Green, Michael V.

PY - 2003

Y1 - 2003

N2 - We evaluated two methods of attenuation correction for the NIH ATLAS small animal PET scanner: 1) a CT-based method that derives 511 keV attenuation coefficients (μ) by extrapolation from spatially registered CT images; and 2) an analytic method based on the body outline of emission images and an empirical μ. A specially fabricated attenuation calibration phantom with cylindrical inserts that mimic different body tissues was used to derive the relationship to convert CT values to (I for PET. The methods were applied to three test data sets: 1) a uniform cylinder phantom, 2) the attenuation calibration phantom, and 3) a mouse injected with [ 18F] FDG. The CT-based attenuation correction factors were larger in non-uniform regions of the imaging subject, e.g. mouse head, than the analytic method. The two methods had similar correction factors for regions with uniform density and detectable emission source distributions.

AB - We evaluated two methods of attenuation correction for the NIH ATLAS small animal PET scanner: 1) a CT-based method that derives 511 keV attenuation coefficients (μ) by extrapolation from spatially registered CT images; and 2) an analytic method based on the body outline of emission images and an empirical μ. A specially fabricated attenuation calibration phantom with cylindrical inserts that mimic different body tissues was used to derive the relationship to convert CT values to (I for PET. The methods were applied to three test data sets: 1) a uniform cylinder phantom, 2) the attenuation calibration phantom, and 3) a mouse injected with [ 18F] FDG. The CT-based attenuation correction factors were larger in non-uniform regions of the imaging subject, e.g. mouse head, than the analytic method. The two methods had similar correction factors for regions with uniform density and detectable emission source distributions.

UR - https://www.scopus.com/pages/publications/11844305968

M3 - Conference article

AN - SCOPUS:11844305968

SN - 1095-7863

VL - 4

SP - 2283

EP - 2287

JO - IEEE Nuclear Science Symposium Conference Record

JF - IEEE Nuclear Science Symposium Conference Record

M1 - M7-27

T2 - 2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference

Y2 - 19 October 2003 through 25 October 2003

ER -

Attenuation correction for the NIH ATLAS small animal PET scanner

Abstract

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