Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype

Brian T. Tsuji; Christof Von Eiff; Pamela A. Kelchlin; Alan Forrest; Patrick F. Smith

doi:10.1128/AAC.01254-07

Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype

Brian T. Tsuji
, Christof Von Eiff
, Pamela A. Kelchlin
, Alan Forrest
, Patrick F. Smith

Pharmacy

University of Münster
SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

Original language	English
Pages (from-to)	1533-1537
Number of pages	5
Journal	Antimicrobial Agents and Chemotherapy
Volume	52
Issue number	4
DOIs	https://doi.org/10.1128/AAC.01254-07
State	Published - Apr 2008

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title = "Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype",

abstract = "The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50\% less effect, a result which was well described by a Hill-type pharmacodynamic model.",

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AU - Forrest, Alan

AU - Smith, Patrick F.

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AB - The in vitro bactericidal activities of vancomycin against Staphylococcus aureus hemB mutants displaying the small-colony-variant phenotype and their parental strains were evaluated. Vancomycin killing activities against hemB mutants were markedly attenuated, demonstrating approximately 50% less effect, a result which was well described by a Hill-type pharmacodynamic model.

UR - https://www.scopus.com/pages/publications/42049122118

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AN - SCOPUS:42049122118

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JO - Antimicrobial Agents and Chemotherapy

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ER -

Attenuated vancomycin bactericidal activity against Staphylococcus aureus hemB mutants expressing the small-colony-variant phenotype

Abstract

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