Atropine induced bradycardia in the guinea pig: dose response

D. Shucard Wm.; M. Andrew

Atropine induced bradycardia in the guinea pig: dose response

D. Shucard Wm.
, M. Andrew

Neurology

National Jewish Medical and Research Center

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effect of atropine sulfate on the heart rate of the unanesthetized guinea pig was studied using a wide range of doses injected via a chronic jugular cannula; dose response data are presented for the range of 5 mg/kg to 50 mg/kg. A long lasting dose dependent bradycardia was produced. This finding is in contrast to the classically reported effect of atropine in man and dog: tachycardia sometimes preceded by a transient bradycardia. Thus, the guinea pig may be an excellent model for the study of parasympathomimetic, bradycardia producing effects of atropine.

Original language	English
Pages (from-to)	401-410
Number of pages	10
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	16
Issue number	3
State	Published - 1977

Cite this

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abstract = "The effect of atropine sulfate on the heart rate of the unanesthetized guinea pig was studied using a wide range of doses injected via a chronic jugular cannula; dose response data are presented for the range of 5 mg/kg to 50 mg/kg. A long lasting dose dependent bradycardia was produced. This finding is in contrast to the classically reported effect of atropine in man and dog: tachycardia sometimes preceded by a transient bradycardia. Thus, the guinea pig may be an excellent model for the study of parasympathomimetic, bradycardia producing effects of atropine.",

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N2 - The effect of atropine sulfate on the heart rate of the unanesthetized guinea pig was studied using a wide range of doses injected via a chronic jugular cannula; dose response data are presented for the range of 5 mg/kg to 50 mg/kg. A long lasting dose dependent bradycardia was produced. This finding is in contrast to the classically reported effect of atropine in man and dog: tachycardia sometimes preceded by a transient bradycardia. Thus, the guinea pig may be an excellent model for the study of parasympathomimetic, bradycardia producing effects of atropine.

AB - The effect of atropine sulfate on the heart rate of the unanesthetized guinea pig was studied using a wide range of doses injected via a chronic jugular cannula; dose response data are presented for the range of 5 mg/kg to 50 mg/kg. A long lasting dose dependent bradycardia was produced. This finding is in contrast to the classically reported effect of atropine in man and dog: tachycardia sometimes preceded by a transient bradycardia. Thus, the guinea pig may be an excellent model for the study of parasympathomimetic, bradycardia producing effects of atropine.

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M3 - Article

C2 - 847295

AN - SCOPUS:0017328370

SN - 0034-5164

VL - 16

SP - 401

EP - 410

JO - Research Communications in Chemical Pathology and Pharmacology

JF - Research Communications in Chemical Pathology and Pharmacology

IS - 3

ER -

Atropine induced bradycardia in the guinea pig: dose response

Abstract

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