Astrocyte Bioenergetics and Major Psychiatric Disorders

Ivan V. Maly; Michael J. Morales; Mikhail V. Pletnikov

doi:10.1007/978-3-030-77375-5_9

Astrocyte Bioenergetics and Major Psychiatric Disorders

Physiology and Biophysics

SUNY Buffalo

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

9 Scopus citations

Abstract

Ongoing research continues to add new elements to the emerging picture of involvement of astrocyte energy metabolism in the pathophysiology of major psychiatric disorders, including schizophrenia, mood disorders, and addictions. This review outlines what is known about the energy metabolism in astrocytes, the most numerous cell type in the brain, and summarizes the recent work on how specific perturbations of astrocyte bioenergetics may contribute to the neuropsychiatric conditions. The role of astrocyte energy metabolism in mental health and disease is reviewed on the organism, organ, and cell level. Data arising from genomic, metabolomic, in vitro, and neurobehavioral studies is critically analyzed to suggest future directions in research and possible metabolism-focused therapeutic interventions.

Original language	English
Title of host publication	Advances in Neurobiology
Publisher	Springer
Pages	173-227
Number of pages	55
DOIs	https://doi.org/10.1007/978-3-030-77375-5_9
State	Published - 2021

Publication series

Name	Advances in Neurobiology
Volume	26
ISSN (Print)	2190-5215
ISSN (Electronic)	2190-5223

Keywords

Astrocyte
Bioenergetics
Glycolysis
Mitochondria
Psychiatric disorders

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10.1007/978-3-030-77375-5_9

Cite this

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abstract = "Ongoing research continues to add new elements to the emerging picture of involvement of astrocyte energy metabolism in the pathophysiology of major psychiatric disorders, including schizophrenia, mood disorders, and addictions. This review outlines what is known about the energy metabolism in astrocytes, the most numerous cell type in the brain, and summarizes the recent work on how specific perturbations of astrocyte bioenergetics may contribute to the neuropsychiatric conditions. The role of astrocyte energy metabolism in mental health and disease is reviewed on the organism, organ, and cell level. Data arising from genomic, metabolomic, in vitro, and neurobehavioral studies is critically analyzed to suggest future directions in research and possible metabolism-focused therapeutic interventions.",

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AU - Morales, Michael J.

AU - Pletnikov, Mikhail V.

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AB - Ongoing research continues to add new elements to the emerging picture of involvement of astrocyte energy metabolism in the pathophysiology of major psychiatric disorders, including schizophrenia, mood disorders, and addictions. This review outlines what is known about the energy metabolism in astrocytes, the most numerous cell type in the brain, and summarizes the recent work on how specific perturbations of astrocyte bioenergetics may contribute to the neuropsychiatric conditions. The role of astrocyte energy metabolism in mental health and disease is reviewed on the organism, organ, and cell level. Data arising from genomic, metabolomic, in vitro, and neurobehavioral studies is critically analyzed to suggest future directions in research and possible metabolism-focused therapeutic interventions.

KW - Astrocyte

KW - Bioenergetics

KW - Glycolysis

KW - Mitochondria

KW - Psychiatric disorders

UR - https://www.scopus.com/pages/publications/85121230075

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M3 - Chapter

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T3 - Advances in Neurobiology

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BT - Advances in Neurobiology

PB - Springer

ER -

Astrocyte Bioenergetics and Major Psychiatric Disorders

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Keywords

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