Abstract
Environmental manganese (Mn) exposure in childhood has been associated with developmental deficits. This study investigated associations between low-level Mn exposure and developmental scores in children aged 14-45 months. Children's hair samples (n = 60) were analyzed for Mn and lead (Pb) using inductively coupled plasma mass spectrometry (ICP-MS). Children were assessed with the Bayley Scales of Infant Development III (BSID). Mean hair Mn and Pb concentrations were 0.98 - 0.74 and 10.1 - 10.5 ?g/g, respectively. Unadjusted inverse associations were seen between Mn and BSID subscales, with girls having lower scores related to Mn than boys. No significant associations remained in covariate-adjusted models, although when stratified by sex boys had a positive association between hair Mn levels and language scores. This study does not show clear evidence of an association between hair Mn concentrations and children's developmental scores in a region of low-level Mn exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 46-54 |
| Number of pages | 9 |
| Journal | Archives of Environmental and Occupational Health |
| Volume | 69 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2014 |
Keywords
- Development
- Manganese
- Preschool
- Uruguay
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